5c2b

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m (Protected "5c2b" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5c2b is ON HOLD
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==anti-CXCL13 parental scFv - 3B4==
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<StructureSection load='5c2b' size='340' side='right' caption='[[5c2b]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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Authors: Tu, C., Bard, J., Mosyak, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5c2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C2B FirstGlance]. <br>
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Description: anti-CXCL13 parental scFv -3B4
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IGHV1-69-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c2b OCA], [http://pdbe.org/5c2b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c2b RCSB], [http://www.ebi.ac.uk/pdbsum/5c2b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5c2b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/HV69D_HUMAN HV69D_HUMAN]] V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).<ref>PMID:17576170</ref> <ref>PMID:20176268</ref> <ref>PMID:22158414</ref> <ref>PMID:24600447</ref> [[http://www.uniprot.org/uniprot/LV211_HUMAN LV211_HUMAN]] V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).<ref>PMID:17576170</ref> <ref>PMID:20176268</ref> <ref>PMID:22158414</ref> <ref>PMID:24600447</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human]]
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[[Category: Bard, J]]
[[Category: Mosyak, L]]
[[Category: Mosyak, L]]
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[[Category: Bard, J]]
 
[[Category: Tu, C]]
[[Category: Tu, C]]
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[[Category: Anti-cxcl13]]
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[[Category: Immune system]]
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[[Category: Scfv]]

Revision as of 09:10, 1 November 2017

anti-CXCL13 parental scFv - 3B4

5c2b, resolution 1.40Å

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