5mp0

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'''Unreleased structure'''
 
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The entry 5mp0 is ON HOLD until Jun 19 2018
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==Human m7GpppN-mRNA Hydrolase (DCP2, NUDT20) Catalytic Domain==
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<StructureSection load='5mp0' size='340' side='right' caption='[[5mp0]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
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Authors: Mathea, S., Salah, E., Velupillai, S., Tallant, C., Pike, A.C.W., Bushell, S.R., Faust, B., Wang, D., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Huber, K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5mp0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MP0 FirstGlance]. <br>
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Description: Human m7GpppN-mRNA Hydrolase (DCP2, NUDT20) Catalytic Domain
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DCP2, NUDT20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-(N(7)-methylguanosine_5'-triphospho)-[mRNA]_hydrolase 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.62 3.6.1.62] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mp0 OCA], [http://pdbe.org/5mp0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mp0 RCSB], [http://www.ebi.ac.uk/pdbsum/5mp0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mp0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/DCP2_HUMAN DCP2_HUMAN]] Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).<ref>PMID:12218187</ref> <ref>PMID:12417715</ref> <ref>PMID:12486012</ref> <ref>PMID:12923261</ref> <ref>PMID:14527413</ref> <ref>PMID:18172165</ref> <ref>PMID:21070968</ref> <ref>PMID:26098573</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Burgess-Brown, N]]
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[[Category: Bushell, S R]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A M]]
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[[Category: Faust, B]]
[[Category: Huber, K]]
[[Category: Huber, K]]
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[[Category: Knapp, S]]
[[Category: Mathea, S]]
[[Category: Mathea, S]]
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[[Category: Pike, A.C.W]]
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[[Category: Pike, A C.W]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Salah, E]]
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[[Category: Burgess-Brown, N]]
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[[Category: Tallant, C]]
[[Category: Velupillai, S]]
[[Category: Velupillai, S]]
[[Category: Wang, D]]
[[Category: Wang, D]]
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[[Category: Von Delft, F]]
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[[Category: Hydrolase]]
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[[Category: Faust, B]]
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[[Category: Mrna decapping]]
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[[Category: Knapp, S]]
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[[Category: Nudix]]
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[[Category: Edwards, A.M]]
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[[Category: Tallant, C]]
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[[Category: Salah, E]]
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[[Category: Bountra, C]]
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[[Category: Bushell, S.R]]
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Revision as of 11:01, 6 November 2017

Human m7GpppN-mRNA Hydrolase (DCP2, NUDT20) Catalytic Domain

5mp0, resolution 1.63Å

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