5v65
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of macrocycles containing Abeta 17-23 (LV(PHI)FAED) and Abeta 30-36 (AII(SAR)L(ORN)V)== | |
| + | <StructureSection load='5v65' size='340' side='right' caption='[[5v65]], [[Resolution|resolution]] 2.52Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5v65]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V65 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V65 FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene>, <scene name='pdbligand=PHI:IODO-PHENYLALANINE'>PHI</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5v63|5v63]], [[5v64|5v64]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v65 OCA], [http://pdbe.org/5v65 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v65 RCSB], [http://www.ebi.ac.uk/pdbsum/5v65 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v65 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The assembly of the beta-amyloid peptide, Abeta, into soluble oligomers is associated with neurodegeneration in Alzheimer's disease. The Abeta oligomers are thought to be composed of beta-hairpins. Here, the effect of shifting the residue pairing of the beta-hairpins on the structures of the oligomers that form is explored through X-ray crystallography. Three residue pairings were investigated using constrained macrocyclic beta-hairpins in which Abeta30-36 is juxtaposed with Abeta17-23, Abeta16-22, and Abeta15-21. The Abeta16-22-Abeta30-36 pairing forms a compact ball-shaped dodecamer composed of fused triangular trimers. This dodecamer may help explain the structures of the trimers and dodecamers formed by full-length Abeta. | ||
| - | + | X-ray Crystallographic Structure of a Compact Dodecamer from a Peptide Derived from Abeta16-36.,Salveson PJ, Spencer RK, Kreutzer AG, Nowick JS Org Lett. 2017 Jul 7;19(13):3462-3465. doi: 10.1021/acs.orglett.7b01445. Epub, 2017 Jun 15. PMID:28683555<ref>PMID:28683555</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5v65" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kreutzer, A G]] | ||
| + | [[Category: Nowick, J S]] | ||
| + | [[Category: Salveson, P J]] | ||
| + | [[Category: Beta-hairpin]] | ||
| + | [[Category: De novo protein]] | ||
| + | [[Category: Macrocycle]] | ||
Revision as of 11:19, 6 November 2017
Crystal structure of macrocycles containing Abeta 17-23 (LV(PHI)FAED) and Abeta 30-36 (AII(SAR)L(ORN)V)
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