1zxc
From Proteopedia
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|PDB= 1zxc |SIZE=350|CAPTION= <scene name='initialview01'>1zxc</scene>, resolution 2.28Å | |PDB= 1zxc |SIZE=350|CAPTION= <scene name='initialview01'>1zxc</scene>, resolution 2.28Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=IH6:(3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE'>IH6</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/ADAM_17_endopeptidase ADAM 17 endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.86 3.4.24.86] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/ADAM_17_endopeptidase ADAM 17 endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.86 3.4.24.86] </span> |
|GENE= ADAM17, CSVP, TACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= ADAM17, CSVP, TACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1bkc|1bkc]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxc OCA], [http://www.ebi.ac.uk/pdbsum/1zxc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zxc RCSB]</span> | ||
}} | }} | ||
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[[Category: Xu, W.]] | [[Category: Xu, W.]] | ||
[[Category: Zhang, Y.]] | [[Category: Zhang, Y.]] | ||
| - | [[Category: IH6]] | ||
| - | [[Category: ZN]] | ||
[[Category: tace-inhibitor complex]] | [[Category: tace-inhibitor complex]] | ||
[[Category: tace/adam-17]] | [[Category: tace/adam-17]] | ||
[[Category: zn-endopeptidase]] | [[Category: zn-endopeptidase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:42:54 2008'' |
Revision as of 22:42, 30 March 2008
| |||||||
| , resolution 2.28Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | ADAM17, CSVP, TACE (Homo sapiens) | ||||||
| Activity: | ADAM 17 endopeptidase, with EC number 3.4.24.86 | ||||||
| Related: | 1bkc
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of catalytic domain of TNF-alpha converting enzyme (TACE) with inhibitor
Overview
The SAR of a series of potent sulfonamide hydroxamate TACE inhibitors bearing a butynyloxy P1' group was explored. In particular, compound 5k has excellent in vitro potency against TACE enzyme and in cells, and oral activity in an in vivo model of TNF-alpha production and a collagen-induced arthritis model.
About this Structure
1ZXC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates., Levin JI, Chen JM, Laakso LM, Du M, Du X, Venkatesan AM, Sandanayaka V, Zask A, Xu J, Xu W, Zhang Y, Skotnicki JS, Bioorg Med Chem Lett. 2005 Oct 1;15(19):4345-9. PMID:16084720
Page seeded by OCA on Mon Mar 31 01:42:54 2008
