4wk7
From Proteopedia
(Difference between revisions)
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<StructureSection load='4wk7' size='340' side='right' caption='[[4wk7]], [[Resolution|resolution]] 1.24Å' scene=''> | <StructureSection load='4wk7' size='340' side='right' caption='[[4wk7]], [[Resolution|resolution]] 1.24Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4wk7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WK7 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4wk7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WK7 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PQ:2-(4-CHLOROPHENOXY)-N-{[(4R)-4-METHYL-2,5-DIOXOIMIDAZOLIDIN-4-YL]METHYL}ACETAMIDE'>3PQ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PQ:2-(4-CHLOROPHENOXY)-N-{[(4R)-4-METHYL-2,5-DIOXOIMIDAZOLIDIN-4-YL]METHYL}ACETAMIDE'>3PQ</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wke|4wke]], [[4wki|4wki]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wke|4wke]], [[4wki|4wki]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADAMTS4, KIAA0688, UNQ769/PRO1563 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ADAMTS-4_endopeptidase ADAMTS-4 endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.82 3.4.24.82] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ADAMTS-4_endopeptidase ADAMTS-4 endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.82 3.4.24.82] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wk7 OCA], [http://pdbe.org/4wk7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wk7 RCSB], [http://www.ebi.ac.uk/pdbsum/4wk7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wk7 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wk7 OCA], [http://pdbe.org/4wk7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wk7 RCSB], [http://www.ebi.ac.uk/pdbsum/4wk7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wk7 ProSAT]</span></td></tr> | ||
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</div> | </div> | ||
<div class="pdbe-citations 4wk7" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4wk7" style="background-color:#fffaf0;"></div> | ||
| - | |||
| - | ==See Also== | ||
| - | *[[A Disintegrin And Metalloproteinase|A Disintegrin And Metalloproteinase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: ADAMTS-4 endopeptidase]] | [[Category: ADAMTS-4 endopeptidase]] | ||
| + | [[Category: Human]] | ||
[[Category: Durbin, J D]] | [[Category: Durbin, J D]] | ||
[[Category: Stout, S L]] | [[Category: Stout, S L]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Inhibitor]] | [[Category: Inhibitor]] | ||
[[Category: Metalloprotease]] | [[Category: Metalloprotease]] | ||
[[Category: Osteoarthritis]] | [[Category: Osteoarthritis]] | ||
Revision as of 12:12, 6 November 2017
Crystal structure of human ADAMTS-4 in complex with inhibitor (compound 1, 2-(4-chlorophenoxy)-N-{[(4R)-4-methyl-2,5-dioxoimidazolidin-4-yl]methyl} acetamide)
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