4zhk
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/RPE65_BOVIN RPE65_BOVIN]] Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.<ref>PMID:16096063</ref> <ref>PMID:19805034</ref> <ref>PMID:20100834</ref> | [[http://www.uniprot.org/uniprot/RPE65_BOVIN RPE65_BOVIN]] Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.<ref>PMID:16096063</ref> <ref>PMID:19805034</ref> <ref>PMID:20100834</ref> | ||
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| - | ==See Also== | ||
| - | *[[Retinoid isomerohydrolase|Retinoid isomerohydrolase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Palczewski, K]] | [[Category: Palczewski, K]] | ||
[[Category: 7-bladed beta propeller]] | [[Category: 7-bladed beta propeller]] | ||
| + | [[Category: Hydrolase]] | ||
[[Category: Isomerase]] | [[Category: Isomerase]] | ||
[[Category: Monotopic membrane protein]] | [[Category: Monotopic membrane protein]] | ||
Revision as of 12:21, 6 November 2017
Crystal structure of RPE65 in complex with MB-002
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