241d
From Proteopedia
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|PDB= 241d |SIZE=350|CAPTION= <scene name='initialview01'>241d</scene>, resolution 1.850Å | |PDB= 241d |SIZE=350|CAPTION= <scene name='initialview01'>241d</scene>, resolution 1.850Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=241d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=241d OCA], [http://www.ebi.ac.uk/pdbsum/241d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=241d RCSB]</span> | ||
}} | }} | ||
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[[Category: u-dna]] | [[Category: u-dna]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:45:02 2008'' |
Revision as of 22:45, 30 March 2008
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| , resolution 1.850Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
EXTENSION OF THE FOUR-STRANDED INTERCALATED CYTOSINE MOTIF BY ADENINE.ADENINE BASE PAIRING IN THE CRYSTAL STRUCTURE OF D(CCCAAT)
Overview
The crystal structure of d(CCCAAT), refined at 2.0 A resolution, shows a four stranded molecule in which two parallel duplexes intercalate with opposite polarity, using cytosine.protonated cytosine base pairs. The intercalation motif in this structure is extended by adenine.adenine base pairs. Two topologically distinct broad grooves are found in the lath-like central part of the molecule with the phosphate groups on one side bent over towards each other, stabilized by bridging water molecules. At the 3' ends, two arrangements of intermolecular A.A.T base triplets are found, involving both asymmetric and symmetric A.A base pairs joined to thymine residues by Watson-Crick and reverse Hoogsteen base pairing, respectively.
About this Structure
241D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Extension of the four-stranded intercalated cytosine motif by adenine.adenine base pairing in the crystal structure of d(CCCAAT)., Berger I, Kang C, Fredian A, Ratliff R, Moyzis R, Rich A, Nat Struct Biol. 1995 May;2(5):416-25. PMID:7664099
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