6bf2

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m (Protected "6bf2" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6bf2 is ON HOLD
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==Solution structure of a Bcl-xL S62E mutant==
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<StructureSection load='6bf2' size='340' side='right' caption='[[6bf2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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Authors: Viacava Follis, A., Phillips, A., Kriwacki, R.K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6bf2]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5l1y 5l1y]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BF2 FirstGlance]. <br>
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Description: Solution structure of a Bcl-xL S62E mutant
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bf2 OCA], [http://pdbe.org/6bf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bf2 RCSB], [http://www.ebi.ac.uk/pdbsum/6bf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bf2 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Kriwacki, R.K]]
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== Function ==
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[[Category: Viacava Follis, A]]
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[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Follis, A Viacava]]
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[[Category: Kriwacki, R W]]
[[Category: Phillips, A]]
[[Category: Phillips, A]]
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[[Category: Apoptosis]]

Revision as of 07:29, 8 November 2017

Solution structure of a Bcl-xL S62E mutant

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