5h4d
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of hSIRT3 in complex with a specific agonist Amiodarone hydrochloride== | |
| - | + | <StructureSection load='5h4d' size='340' side='right' caption='[[5h4d]], [[Resolution|resolution]] 3.21Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5h4d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H4D FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BBI:(2-BUTYL-1-BENZOFURAN-3-YL){4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYL}METHANONE'>BBI</scene>, <scene name='pdbligand=FDL:N~6~-ACETYL-N-(4-METHYL-2-OXO-2H-CHROMEN-7-YL)-L-LYSINAMIDE'>FDL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h4d OCA], [http://pdbe.org/5h4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h4d RCSB], [http://www.ebi.ac.uk/pdbsum/5h4d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h4d ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN]] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fu, L]] | ||
| + | [[Category: Liu, B]] | ||
| + | [[Category: Liu, J]] | ||
| + | [[Category: Zhang, S]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Sirt3 amiodarone agonist]] | ||
Revision as of 07:45, 8 November 2017
Crystal structure of hSIRT3 in complex with a specific agonist Amiodarone hydrochloride
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Categories: Fu, L | Liu, B | Liu, J | Zhang, S | Hydrolase | Sirt3 amiodarone agonist
