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5vki
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of P[19] rotavirus VP8* complexed with mucin core 2== | |
| - | + | <StructureSection load='5vki' size='340' side='right' caption='[[5vki]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5vki]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VKI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VKI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THR:THREONINE'>THR</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vks|5vks]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vki OCA], [http://pdbe.org/5vki PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vki RCSB], [http://www.ebi.ac.uk/pdbsum/5vki PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vki ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/A7YCM0_9REOV A7YCM0_9REOV]] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS00846030] VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.[SAAS:SAAS00846016] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Jiang, X]] | ||
| + | [[Category: Kennedy, M A]] | ||
[[Category: Liu, Y]] | [[Category: Liu, Y]] | ||
| + | [[Category: Woodruff, A]] | ||
| + | [[Category: Xu, S]] | ||
[[Category: Zhong, W]] | [[Category: Zhong, W]] | ||
| - | [[Category: | + | [[Category: Complex]] |
| - | [[Category: | + | [[Category: Mucin core 2]] |
| - | [[Category: | + | [[Category: Viral protein]] |
| - | + | ||
Revision as of 07:49, 8 November 2017
Crystal structure of P[19] rotavirus VP8* complexed with mucin core 2
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Categories: Jiang, X | Kennedy, M A | Liu, Y | Woodruff, A | Xu, S | Zhong, W | Complex | Mucin core 2 | Viral protein
