6ayf

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m (Protected "6ayf" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6ayf is ON HOLD
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==TRPML3/ML-SA1 complex at pH 7.4==
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<StructureSection load='6ayf' size='340' side='right' caption='[[6ayf]], [[Resolution|resolution]] 3.62&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6ayf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AYF FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ayf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ayf OCA], [http://pdbe.org/6ayf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ayf RCSB], [http://www.ebi.ac.uk/pdbsum/6ayf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ayf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MCLN3_HUMAN MCLN3_HUMAN]] Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:18369318, PubMed:19497048, PubMed:19522758, PubMed:19885840). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (PubMed:21245134). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (By similarity). Involved in the regulation of autophagy (PubMed:19522758). Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (PubMed:23469151).[UniProtKB:Q8R4F0]<ref>PMID:18369318</ref> <ref>PMID:19497048</ref> <ref>PMID:19522758</ref> <ref>PMID:19885840</ref> <ref>PMID:21245134</ref> <ref>PMID:23469151</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Jia, Q]]
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[[Category: Li, H]]
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[[Category: Li, M]]
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[[Category: Li, X]]
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[[Category: Su, D]]
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[[Category: Yang, J]]
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[[Category: Zhou, X]]
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[[Category: Ion channel]]
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[[Category: Lysosomal]]
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[[Category: Transport protein]]
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[[Category: Trp channel]]

Revision as of 07:54, 8 November 2017

TRPML3/ML-SA1 complex at pH 7.4

6ayf, resolution 3.62Å

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