2a6r

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|PDB= 2a6r |SIZE=350|CAPTION= <scene name='initialview01'>2a6r</scene>, resolution 2.05&Aring;
|PDB= 2a6r |SIZE=350|CAPTION= <scene name='initialview01'>2a6r</scene>, resolution 2.05&Aring;
|SITE=
|SITE=
-
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
+
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= yoeB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
|GENE= yoeB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
 +
|DOMAIN=
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|RELATEDENTRY=[[2a6q|2A6Q]], [[2a6s|2A6S]]
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a6r OCA], [http://www.ebi.ac.uk/pdbsum/2a6r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a6r RCSB]</span>
}}
}}
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[[Category: Hanaoka, F.]]
[[Category: Hanaoka, F.]]
[[Category: Kamada, K.]]
[[Category: Kamada, K.]]
-
[[Category: MG]]
 
[[Category: addiction module]]
[[Category: addiction module]]
[[Category: antitoxin]]
[[Category: antitoxin]]
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[[Category: yoeb]]
[[Category: yoeb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:46:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:48:33 2008''

Revision as of 22:48, 30 March 2008

Image:2a6r.gif


PDB ID 2a6r

Drag the structure with the mouse to rotate
, resolution 2.05Å
Ligands:
Gene: yoeB (Escherichia coli)
Related: 2A6Q, 2A6S


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of YoeB under PEG condition


Overview

The eubacterial chromosome encodes various addiction modules that control global levels of translation through RNA degradation. Crystal structures of the Escherichia coli YefM2 (antitoxin)-YoeB (toxin) complex and the free YoeB toxin have been determined. The structure of the heterotrimeric complex reveals an asymmetric disorder-to-order recognition strategy, in which one C terminus of the YefM homodimer exclusively interacts with an atypical microbial ribonuclease (RNase) fold of YoeB. Comparison with the YefM-free YoeB structure indicates a conformational rearrangement of the RNase catalytic site of YoeB, induced by interaction with YefM. Complementary biochemical experiments demonstrate that the YoeB toxin has an in vitro RNase activity that preferentially cleaves at the 3' end of purine ribonucleotides.

About this Structure

2A6R is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Conformational change in the catalytic site of the ribonuclease YoeB toxin by YefM antitoxin., Kamada K, Hanaoka F, Mol Cell. 2005 Aug 19;19(4):497-509. PMID:16109374

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