3v3k
From Proteopedia
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/CASP9_HUMAN CASP9_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).<ref>PMID:15657060</ref> Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<ref>PMID:15657060</ref> [[http://www.uniprot.org/uniprot/NLEF_ECO57 NLEF_ECO57]] Effector protein that alters host cell physiology and promotes bacterial survival in host tissues. Inhibits the catalytic activity of human CASP4, CASP8 and CASP9, and thereby inhibits apoptosis of infected host cells.<ref>PMID:18279332</ref> <ref>PMID:23516580</ref> | [[http://www.uniprot.org/uniprot/CASP9_HUMAN CASP9_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).<ref>PMID:15657060</ref> Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<ref>PMID:15657060</ref> [[http://www.uniprot.org/uniprot/NLEF_ECO57 NLEF_ECO57]] Effector protein that alters host cell physiology and promotes bacterial survival in host tissues. Inhibits the catalytic activity of human CASP4, CASP8 and CASP9, and thereby inhibits apoptosis of infected host cells.<ref>PMID:18279332</ref> <ref>PMID:23516580</ref> | ||
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| - | ==See Also== | ||
| - | *[[Caspase|Caspase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 10:11, 8 November 2017
Human caspase 9 in complex with bacterial effector protein
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Categories: Caspase-9 | Eco57 | Human | Maskos, K | Moertl, M | Steuber, H | Caspase 9 | Hydrolase
