2aaq
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
|PDB= 2aaq |SIZE=350|CAPTION= <scene name='initialview01'>2aaq</scene>, resolution 2.60Å | |PDB= 2aaq |SIZE=350|CAPTION= <scene name='initialview01'>2aaq</scene>, resolution 2.60Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=AUP:2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINE'>AUP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Glutathione-disulfide_reductase Glutathione-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.7 1.8.1.7] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione-disulfide_reductase Glutathione-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.7 1.8.1.7] </span> |
|GENE= hGR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= hGR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aaq OCA], [http://www.ebi.ac.uk/pdbsum/2aaq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2aaq RCSB]</span> | ||
}} | }} | ||
'''Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI''' | '''Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI''' | ||
| - | |||
| - | ==Disease== | ||
| - | Known diseases associated with this structure: Hemolytic anemia due to glutathione reductase deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138300 138300]], Mental retardation, autosomal recessive, 6 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138244 138244]] | ||
==About this Structure== | ==About this Structure== | ||
| Line 30: | Line 30: | ||
[[Category: Toth, K.]] | [[Category: Toth, K.]] | ||
[[Category: Urig, S.]] | [[Category: Urig, S.]] | ||
| - | [[Category: AU]] | ||
| - | [[Category: AUP]] | ||
| - | [[Category: CL]] | ||
| - | [[Category: FAD]] | ||
| - | [[Category: GOL]] | ||
| - | [[Category: K]] | ||
| - | [[Category: PO4]] | ||
[[Category: antioxidative system]] | [[Category: antioxidative system]] | ||
[[Category: disulfide reductase]] | [[Category: disulfide reductase]] | ||
| Line 44: | Line 37: | ||
[[Category: protein gold complex]] | [[Category: protein gold complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:50:15 2008'' |
Revision as of 22:50, 30 March 2008
| |||||||
| , resolution 2.60Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , , , | ||||||
| Gene: | hGR (Homo sapiens) | ||||||
| Activity: | Glutathione-disulfide reductase, with EC number 1.8.1.7 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI
About this Structure
2AAQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases., Urig S, Fritz-Wolf K, Reau R, Herold-Mende C, Toth K, Davioud-Charvet E, Becker K, Angew Chem Int Ed Engl. 2006 Mar 13;45(12):1881-6. PMID:16493712
Page seeded by OCA on Mon Mar 31 01:50:15 2008
Categories: Glutathione-disulfide reductase | Homo sapiens | Single protein | Becker, K. | Davioud-Charvet, E. | Fritz-Wolf, K. | Herold-Mende, C. | Reau, R. | Toth, K. | Urig, S. | Antioxidative system | Disulfide reductase | Glutathione reduction | Gold-coordination | Homodimer | Protein gold complex
