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1csr
From Proteopedia
(Difference between revisions)
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==Alpha-fluoro acid and alpha-fluoro amide analogs of acetyl-coa as inhibitors of of citrate synthase: effect of pka matching on binding affinity and hydrogen bond length== | ==Alpha-fluoro acid and alpha-fluoro amide analogs of acetyl-coa as inhibitors of of citrate synthase: effect of pka matching on binding affinity and hydrogen bond length== | ||
<StructureSection load='1csr' size='340' side='right' caption='[[1csr]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='1csr' size='340' side='right' caption='[[1csr]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1csr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1csr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CSR FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAM:ALPHA-FLUORO-AMIDOCARBOXYMETHYLDETHIA+COENZYME+A+COMPLEX'>FAM</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAM:ALPHA-FLUORO-AMIDOCARBOXYMETHYLDETHIA+COENZYME+A+COMPLEX'>FAM</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Citrate_(Si)-synthase Citrate (Si)-synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.1 2.3.3.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Citrate_(Si)-synthase Citrate (Si)-synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.1 2.3.3.1] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1csr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1csr OCA], [http://pdbe.org/1csr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1csr RCSB], [http://www.ebi.ac.uk/pdbsum/1csr PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1csr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1csr OCA], [http://pdbe.org/1csr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1csr RCSB], [http://www.ebi.ac.uk/pdbsum/1csr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1csr ProSAT]</span></td></tr> |
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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</div> | </div> | ||
<div class="pdbe-citations 1csr" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1csr" style="background-color:#fffaf0;"></div> | ||
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| - | ==See Also== | ||
| - | *[[Citrate Synthase|Citrate Synthase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Gallus gallus]] |
[[Category: Remington, S J]] | [[Category: Remington, S J]] | ||
[[Category: Usher, K C]] | [[Category: Usher, K C]] | ||
[[Category: Oxo-acid-lyase]] | [[Category: Oxo-acid-lyase]] | ||
Revision as of 10:58, 8 November 2017
Alpha-fluoro acid and alpha-fluoro amide analogs of acetyl-coa as inhibitors of of citrate synthase: effect of pka matching on binding affinity and hydrogen bond length
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