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Thymidylate synthase

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Line 23: Line 23:
**[[1tis]] – TS – ''Enterobacteria'' phage T4<br />
**[[1tis]] – TS – ''Enterobacteria'' phage T4<br />
**[[1bsf]], [[1bko]], [[1bkp]], [[1bsp]] - BsTS - ''Bacillus subtilis''<br />
**[[1bsf]], [[1bko]], [[1bkp]], [[1bsp]] - BsTS - ''Bacillus subtilis''<br />
-
**[[1hw3]], [[1hw4]], [[1hzw]], [[1ypv]], [[2onb]], [[4gyh]], [[4h1i]], [[4up1]]- hTS – human<br />
+
**[[1hw3]], [[1hw4]], [[1hzw]], [[1ypv]], [[2onb]], [[4gyh]], [[4h1i]], [[4up1]], [[5x5a]], [[5x69]] - hTS – human<br />
**[[3n5g]], [[4kpw]] – hTS His-tag<br />
**[[3n5g]], [[4kpw]] – hTS His-tag<br />
-
**[[2rd8]], [[2rda]], [[3egy]], [[3ehi]], [[3eaw]], [[3ebu]], [[3ed7]], [[3edw]], [[3ef9]], [[3ejl]], [[3gg5]], [[3gh0]], [[3gh2]], [[4jef]], [[4o1u]], [[4o1x]] – hTS (mutant)<br />
+
**[[2rd8]], [[2rda]], [[3egy]], [[3ehi]], [[3eaw]], [[3ebu]], [[3ed7]], [[3edw]], [[3ef9]], [[3ejl]], [[3gg5]], [[3gh0]], [[3gh2]], [[4jef]], [[4o1u]], [[4o1x]], [[5x4w]], [[5x4x]], [[5x4y]] – hTS (mutant)<br />
**[[3ix6]] – BmTS – ''Brucella melitensis''<br />
**[[3ix6]] – BmTS – ''Brucella melitensis''<br />
**[[3kgb]] – TS – ''Encephalitozoon cuniculi''<br />
**[[3kgb]] – TS – ''Encephalitozoon cuniculi''<br />
Line 33: Line 33:
**[[4iqb]] – nTS – nematode<br />
**[[4iqb]] – nTS – nematode<br />
**[[4xse]] - VvTS – Varicella-zoster virus<br />
**[[4xse]] - VvTS – Varicella-zoster virus<br />
 +
**[[6auj]] - TS – ''Elizabethkingia anophelis''<br />
*Thymidylate synthase binary complex
*Thymidylate synthase binary complex
-
**[[1tdc]], [[1thy]], [[2tdm]] – LcTS + UMP<BR />
+
**[[1tdc]], [[1thy]], [[2tdm]], [[5x5d]] – LcTS + UMP<BR />
**[[1tsv]], [[1tsx]], [[1tsy]], [[1njd]], [[1njb]], [[1vza]], [[1vzb]], [[1jmf]], [[1jmg]], [[1jmh]], [[1jmi]], [[1bo7]], [[1bo8]], [[1bp6]], [[1bpj]], [[1bp0]], [[2g86]], [[2g89]], [[2g8a]], [[2g8d]] - LcTS (mutant) + UMP<BR />
**[[1tsv]], [[1tsx]], [[1tsy]], [[1njd]], [[1njb]], [[1vza]], [[1vzb]], [[1jmf]], [[1jmg]], [[1jmh]], [[1jmi]], [[1bo7]], [[1bo8]], [[1bp6]], [[1bpj]], [[1bp0]], [[2g86]], [[2g89]], [[2g8a]], [[2g8d]] - LcTS (mutant) + UMP<BR />
**[[1vzc]] - LcTS (mutant) + fluoro-UMP<BR />
**[[1vzc]] - LcTS (mutant) + fluoro-UMP<BR />
Line 57: Line 58:
**[[3h9k]] - hTS (mutant) + fluoro-UMP<BR />
**[[3h9k]] - hTS (mutant) + fluoro-UMP<BR />
**[[3hb8]] - hTS (mutant) + UMP<BR />
**[[3hb8]] - hTS (mutant) + UMP<BR />
 +
**[[5wrn]] - hTS + CMP<br />
**[[3ob7]] - hTS (mutant) + glutathione<br />
**[[3ob7]] - hTS (mutant) + glutathione<br />
**[[4g2o]] – hTS (mutant) + purpurogallin<br />
**[[4g2o]] – hTS (mutant) + purpurogallin<br />
Line 67: Line 69:
**[[4ein]] – mTS + substrate analog<br />
**[[4ein]] – mTS + substrate analog<br />
**[[3uwl]] – EfTS + 5-formyl tetrahydrofolate – ''Enterococcus faecalis''<br >
**[[3uwl]] – EfTS + 5-formyl tetrahydrofolate – ''Enterococcus faecalis''<br >
 +
**[[5j7w]] – EfTS + drug <br >
**[[4psg]] – nTS + inhibitor <br >
**[[4psg]] – nTS + inhibitor <br >
**[[5by6]] – TS + UMP – ''Trichinella spiralis''<br />
**[[5by6]] – TS + UMP – ''Trichinella spiralis''<br />
Line 100: Line 103:
**[[4knz]] - EcTS + deoxyuridine derivative + folate derivative<br />
**[[4knz]] - EcTS + deoxyuridine derivative + folate derivative<br />
**[[1rts]], [[2tsr]] - TS + drug + UMP – rat<br />
**[[1rts]], [[2tsr]] - TS + drug + UMP – rat<br />
-
**[[1hvy]], [[1i00]] - hTS + drug + UMP<BR />
+
**[[1hvy]], [[1i00]], [[5x5q]], [[5x66]], [[5x67]] - hTS + drug + UMP<BR />
**[[1e2d]], [[1e2e]], [[1e2f]] - hTS (mutant) + ADP + TMP<BR />
**[[1e2d]], [[1e2e]], [[1e2f]] - hTS (mutant) + ADP + TMP<BR />
 +
**[[5hs3]] - hTS + inhibitor + UMP<br />
**[[1ju6]], [[1juj]] - hTS (mutant) + inhibitor+ UMP<BR />
**[[1ju6]], [[1juj]] - hTS (mutant) + inhibitor+ UMP<BR />
 +
**[[5noo]] - TS + drug + UMP – ''Caenorhabditis enegans''<br />
**[[1b02]] - BsTS + inhibitor+ fluoro-UMP<BR />
**[[1b02]] - BsTS + inhibitor+ fluoro-UMP<BR />
**[[1ci7]] - PcTS + inhibitor+ UMP – ''Pneumocystis carinii''<br />
**[[1ci7]] - PcTS + inhibitor+ UMP – ''Pneumocystis carinii''<br />
Line 110: Line 115:
**[[4fog]] - MtTS + fluoro-UMP + methy-DHF<br />
**[[4fog]] - MtTS + fluoro-UMP + methy-DHF<br />
**[[4fox]], [[4fqs]] - MtTS + inhibitor + fluoro-UMP <br />
**[[4fox]], [[4fqs]] - MtTS + inhibitor + fluoro-UMP <br />
 +
**[[5fct]] - mTS + inhibitor + fluoro-UMP <br />
**[[4ez8]] – mTS + substrate analog + dihydrofolate<br />
**[[4ez8]] – mTS + substrate analog + dihydrofolate<br />
**[[4eb4]] - mTS + drug + UMP<BR />
**[[4eb4]] - mTS + drug + UMP<BR />
-
**[[4iqq]] – nTS + UMP + raltitrexed<br />
+
**[[4iqq]] – nTS + UMP + drug<br />
**[[4o7u]] - EfTS + phthalimidic derivative + folate derivative<br />
**[[4o7u]] - EfTS + phthalimidic derivative + folate derivative<br />
Line 123: Line 129:
**[[2cfa]] - TS + FAD – ''Paramecium bursaria chlorella'' virus<br />
**[[2cfa]] - TS + FAD – ''Paramecium bursaria chlorella'' virus<br />
**[[2gq2]] - MtTS (mutant) + NADP<br />
**[[2gq2]] - MtTS (mutant) + NADP<br />
-
**[[3g4a]], [[3g4c]], [[3n0b]], [[3n0c]] - TS (mutant) + FAD + UMP – ''Thermotoga maritima''<br />
+
**[[5jfe]] - TmTS + FAD + UMP – ''Thermotoga maritima''<br />
 +
**[[3g4a]], [[3g4c]], [[3n0b]], [[3n0c]] - TS (mutant) + FAD + UMP <br />
**[[1o24]] – TmTS<br />
**[[1o24]] – TmTS<br />
**[[1o25]] – TmTS + UMP<br />
**[[1o25]] – TmTS + UMP<br />
Line 129: Line 136:
**[[4gtc]], [[4gtl]], [[4kar]] – TmTS (mutant) + FAD <br />
**[[4gtc]], [[4gtl]], [[4kar]] – TmTS (mutant) + FAD <br />
**[[1o26]] – TmTS + FAD + UMP<br />
**[[1o26]] – TmTS + FAD + UMP<br />
-
**[[4gtd]], [[4kas]], [[4kat]] – TmTS (mutant) + FAD + UMP<br />
+
**[[4gtd]], [[4kas]], [[4kat]], [[5iot]] – TmTS (mutant) + FAD + UMP<br />
**[[1o27]], [[1o28]], [[1o29]] – TmTS + FAD + halo-UMP<br />
**[[1o27]], [[1o28]], [[1o29]] – TmTS + FAD + halo-UMP<br />
**[[1o2b]] – TmTS + FAD + phosphate<br />
**[[1o2b]] – TmTS + FAD + phosphate<br />
Line 136: Line 143:
**[[4gtf]] – TmTS (mutant) + FAD + UMP + folate<br />
**[[4gtf]] – TmTS (mutant) + FAD + UMP + folate<br />
**[[4gte]] – TmTS (mutant) + FAD + folate<br />
**[[4gte]] – TmTS (mutant) + FAD + folate<br />
-
**[[4gtb]] – TmTS + FAD + UMP + raltitrexed<br />
+
**[[4gtb]] – TmTS + FAD + UMP + drug<br />
 +
**[[5chp]] – TmTS + FAD + UMP + inhibitor<br />
**[[5ioq]], [[5ior]] – TmTS + FAD + d-Uridine derivative<br />
**[[5ioq]], [[5ior]] – TmTS + FAD + d-Uridine derivative<br />
**[[5ios]], [[2iot]] – TmTS (mutant) + FAD + dUMP<br />
**[[5ios]], [[2iot]] – TmTS (mutant) + FAD + dUMP<br />
Line 142: Line 150:
**[[3fnn]] - CgTS + FAD <br />
**[[3fnn]] - CgTS + FAD <br />
**[[3ah5]], [[3n3y]] - TS + FAD + UMP – ''Helicobacter pylori''<br />
**[[3ah5]], [[3n3y]] - TS + FAD + UMP – ''Helicobacter pylori''<br />
-
**[[4p5a]], [[5p5b]] – TS + FAD + dUMP derivative – ''Streptomyces cacaoi''<br />
+
**[[4p5a]], [[4p5b]] – TS + FAD + dUMP derivative – ''Streptomyces cacaoi''<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:43, 9 November 2017

Thymidylate synthase complex with dUMP (PDB entry 1tsv)

Drag the structure with the mouse to rotate

3D structures of thymidylate synthase

Updated on 09-November-2017

References

  1. ↑ Kaneda S, Nalbantoglu J, Takeishi K, Shimizu K, Gotoh O, Seno T, Ayusawa D. Structural and functional analysis of the human thymidylate synthase gene. J Biol Chem. 1990 Nov 25;265(33):20277-84. PMID:2243092
  2. ↑ Rahman L, Voeller D, Rahman M, Lipkowitz S, Allegra C, Barrett JC, Kaye FJ, Zajac-Kaye M. Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme. Cancer Cell. 2004 Apr;5(4):341-51. PMID:15093541
  3. ↑ Finer-Moore JS, Fauman EB, Morse RJ, Santi DV, Stroud RM. Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng. 1996 Jan;9(1):69-75. PMID:9053905
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