Topoisomerase

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Line 688: Line 688:
**[[3ksa]], [[2ksb]] – SpTOPIIA+DNA – ''Streptococcus pneumoniae''<br />
**[[3ksa]], [[2ksb]] – SpTOPIIA+DNA – ''Streptococcus pneumoniae''<br />
**[[1zxm]] – hTOPIIA+AMP-PNP <br />
**[[1zxm]] – hTOPIIA+AMP-PNP <br />
-
**[[1zxn]] - hTOPIIA+ADP<br />
+
**[[1zxn]], [[4r1f]] - hTOPIIA+ADP<br />
**[[4fm9]] - hTOPIIA+DNA<br />
**[[4fm9]] - hTOPIIA+DNA<br />
 +
**[[5gwk]] - hTOPIIA+DNA + drug<br />
**[[4elz]] – TOPII residues 362-493 + CCDB – ''Vibrio fischeri''<br />
**[[4elz]] – TOPII residues 362-493 + CCDB – ''Vibrio fischeri''<br />
Line 702: Line 703:
**[[1d3y]] - TOPIIB subunit A - ''Methanocaldococcus janaschii''<br />
**[[1d3y]] - TOPIIB subunit A - ''Methanocaldococcus janaschii''<br />
**[[4j3n]] - hTOPIIB subunit A+B + DNA <br />
**[[4j3n]] - hTOPIIB subunit A+B + DNA <br />
-
**[[4g0w]], [[3qx3]], [[4g0v]], [[4g0u]] - hTOPIIB + DNA + anti-cancer drug<br />
+
**[[4g0w]], [[3qx3]], [[4g0v]], [[4g0u]], [[5gwj]], [[5gwi]] - hTOPIIB + DNA + anti-cancer drug<br />
*Topoisomerase III
*Topoisomerase III
Line 709: Line 710:
**[[1d6m]] - EcTOPIII<br />
**[[1d6m]] - EcTOPIII<br />
**[[4cgy]], [[4cht]] – hTOPIIIα + RecQ-mediated genome instability protein<br />
**[[4cgy]], [[4cht]] – hTOPIIIα + RecQ-mediated genome instability protein<br />
 +
**[[5gvc]] – hTOPIIIβ topo domain<br />
 +
**[[5gve]] – hTOPIIIβ topo domain + Tudor domain-containing protein<br />
*Topoisomerase IV
*Topoisomerase IV
Line 722: Line 725:
**[[4kpe]], [[3foe]], [[3fof]], [[4kpf]] - SpTOPIV subunit A+B (mutant) +DNA + quinolone derivative<br />
**[[4kpe]], [[3foe]], [[3fof]], [[4kpf]] - SpTOPIV subunit A+B (mutant) +DNA + quinolone derivative<br />
**[[3raf]], [[3ltn]] - SpTOPIV subunit A+B+DNA+quinazoline derivative<br />
**[[3raf]], [[3ltn]] - SpTOPIV subunit A+B+DNA+quinazoline derivative<br />
 +
**[[4z53]], [[4z4q]], [[4z3o]] - SpTOPIV subunit A+B+DNA+ drug<br />
**[[2nov]] - SpTOPIV subunit A<br />
**[[2nov]] - SpTOPIV subunit A<br />
**[[4em7]], [[4emv]], [[4lp0]], [[4lpb]], [[4mb9]], [[4mbc]], [[4mot]], [[5boc]], [[5bod]] - SpTOPIV subunit B + inhibitor<br />
**[[4em7]], [[4emv]], [[4lp0]], [[4lpb]], [[4mb9]], [[4mbc]], [[4mot]], [[5boc]], [[5bod]] - SpTOPIV subunit B + inhibitor<br />
 +
**[[5j5q]], [[5j5p]] - SpTOPIV subunit B + DNA<br />
**[[2inr]] - SaTOPIV subunit A – ''Staphylococcus aureus''<br />
**[[2inr]] - SaTOPIV subunit A – ''Staphylococcus aureus''<br />
**[[4url]], [[4urn]] - SaTOPIV subunit B N terminal + antibiotic<br />
**[[4url]], [[4urn]] - SaTOPIV subunit B N terminal + antibiotic<br />

Revision as of 09:10, 9 November 2017

Topoisomerase I complex with DNA and phosphotyrosine (PDB entry 2h7f)

Drag the structure with the mouse to rotate

3D Structures of Topoisomerase

Updated on 09-November-2017

References

  1. ↑ Champoux JJ. DNA topoisomerases: structure, function, and mechanism. Annu Rev Biochem. 2001;70:369-413. PMID:11395412 doi:http://dx.doi.org/10.1146/annurev.biochem.70.1.369
  2. ↑ Slesarev AI, Stetter KO, Lake JA, Gellert M, Krah R, Kozyavkin SA. DNA topoisomerase V is a relative of eukaryotic topoisomerase I from a hyperthermophilic prokaryote. Nature. 1993 Aug 19;364(6439):735-7. PMID:8395022 doi:http://dx.doi.org/10.1038/364735a0
  3. ↑ Coss A, Tosetto M, Fox EJ, Sapetto-Rebow B, Gorman S, Kennedy BN, Lloyd AT, Hyland JM, O'Donoghue DP, Sheahan K, Leahy DT, Mulcahy HE, O'Sullivan JN. Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis. Cancer Lett. 2009 Apr 18;276(2):228-38. doi: 10.1016/j.canlet.2008.11.018. Epub, 2008 Dec 25. PMID:19111388 doi:http://dx.doi.org/10.1016/j.canlet.2008.11.018
  4. ↑ Tse-Dinh YC. Exploring DNA topoisomerases as targets of novel therapeutic agents in the treatment of infectious diseases. Infect Disord Drug Targets. 2007 Mar;7(1):3-9. PMID:17346206


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Michal Harel, Joel L. Sussman, Alexander Berchansky, Jaime Prilusky

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