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5vx3

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m (Protected "5vx3" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5vx3 is ON HOLD until Paper Publication
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==Bcl-xL in complex with Bim-h3Pc-RT==
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<StructureSection load='5vx3' size='340' side='right' caption='[[5vx3]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5vx3]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VX3 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=9R1:'>9R1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vx3 OCA], [http://pdbe.org/5vx3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vx3 RCSB], [http://www.ebi.ac.uk/pdbsum/5vx3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vx3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> [[http://www.uniprot.org/uniprot/B2L11_HUMAN B2L11_HUMAN]] Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.<ref>PMID:9430630</ref> <ref>PMID:11734221</ref> <ref>PMID:12019181</ref> <ref>PMID:11997495</ref> <ref>PMID:15147734</ref> <ref>PMID:15486195</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Brouwer, J M]]
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[[Category: Colman, P M]]
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[[Category: Cowan, A D]]
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[[Category: Czabotar, P E]]
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[[Category: Apoptosis]]
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[[Category: Bcl-2 family]]
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[[Category: Pro-survival]]

Revision as of 07:34, 15 November 2017

Bcl-xL in complex with Bim-h3Pc-RT

5vx3, resolution 1.94Å

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