5wdm

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m (Protected "5wdm" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5wdm is ON HOLD until Paper Publication
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==An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein==
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<StructureSection load='5wdm' size='340' side='right' caption='[[5wdm]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5wdm]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WDM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WDM FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wdm OCA], [http://pdbe.org/5wdm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wdm RCSB], [http://www.ebi.ac.uk/pdbsum/5wdm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wdm ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/A6XGL2_HUMAN A6XGL2_HUMAN]] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity).[SAAS:SAAS022353_004_028339]
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__TOC__
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</StructureSection>
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[[Category: Aldabbagh, K]]
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[[Category: Peng, Y]]
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[[Category: Yee, V C]]
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[[Category: Designed insulin]]
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[[Category: Hexamer]]
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[[Category: Hormone]]
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[[Category: Single chain]]

Revision as of 07:35, 15 November 2017

An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein

5wdm, resolution 2.80Å

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