5yi4
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution Structure of the DISC1/Ndel1 complex== | |
| - | + | <StructureSection load='5yi4' size='340' side='right' caption='[[5yi4]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5yi4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YI4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yi4 OCA], [http://pdbe.org/5yi4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yi4 RCSB], [http://www.ebi.ac.uk/pdbsum/5yi4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yi4 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DISC1_MOUSE DISC1_MOUSE]] Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.<ref>PMID:17825401</ref> <ref>PMID:19303846</ref> <ref>PMID:19502360</ref> <ref>PMID:19778506</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Ye, F]] | ||
| + | [[Category: Yu, C]] | ||
[[Category: Zhang, M]] | [[Category: Zhang, M]] | ||
| - | [[Category: | + | [[Category: Coiled coil]] |
| - | [[Category: | + | [[Category: Disc1]] |
| + | [[Category: Ndel1]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Psychiatric disorder]] | ||
Revision as of 07:39, 15 November 2017
Solution Structure of the DISC1/Ndel1 complex
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Categories: Ye, F | Yu, C | Zhang, M | Coiled coil | Disc1 | Ndel1 | Protein binding | Psychiatric disorder
