6erp
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the human mitochondrial transcription initiation complex at the LSP promoter== | |
| - | + | <StructureSection load='6erp' size='340' side='right' caption='[[6erp]], [[Resolution|resolution]] 4.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6erp]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ERP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ERP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6erp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6erp OCA], [http://pdbe.org/6erp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6erp RCSB], [http://www.ebi.ac.uk/pdbsum/6erp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6erp ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/RPOM_HUMAN RPOM_HUMAN]] DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates.<ref>PMID:21278163</ref> [[http://www.uniprot.org/uniprot/TFAM_HUMAN TFAM_HUMAN]] Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.<ref>PMID:1737790</ref> <ref>PMID:20410300</ref> <ref>PMID:19304746</ref> <ref>PMID:22037172</ref> <ref>PMID:22037171</ref> [[http://www.uniprot.org/uniprot/TFB2M_HUMAN TFB2M_HUMAN]] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.<ref>PMID:12068295</ref> <ref>PMID:12897151</ref> <ref>PMID:15526033</ref> <ref>PMID:20410300</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: DNA-directed RNA polymerase]] | ||
[[Category: Cramer, P]] | [[Category: Cramer, P]] | ||
| - | [[Category: Hillen, H | + | [[Category: Hillen, H S]] |
| + | [[Category: Morozov, Y I]] | ||
[[Category: Sarfallah, A]] | [[Category: Sarfallah, A]] | ||
| + | [[Category: Temiakov, D]] | ||
| + | [[Category: Initiation]] | ||
| + | [[Category: Mitochondria]] | ||
| + | [[Category: Polymerase]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 07:42, 15 November 2017
Structure of the human mitochondrial transcription initiation complex at the LSP promoter
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