2afr
From Proteopedia
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|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= | ||
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Precorrin-8X_methylmutase Precorrin-8X methylmutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.1.2 5.4.1.2] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Precorrin-8X_methylmutase Precorrin-8X methylmutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.1.2 5.4.1.2] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2afv|2AFV]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2afr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2afr OCA], [http://www.ebi.ac.uk/pdbsum/2afr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2afr RCSB]</span> | ||
}} | }} | ||
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[[Category: isomerase]] | [[Category: isomerase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:52:04 2008'' |
Revision as of 22:52, 30 March 2008
| |||||||
| , resolution 2.30Å | |||||||
|---|---|---|---|---|---|---|---|
| Activity: | Precorrin-8X methylmutase, with EC number 5.4.1.2 | ||||||
| Related: | 2AFV
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The Crystal Structure of Putative Precorrin Isomerase CbiC in Cobalamin Biosynthesis
Overview
The leptospira cbiC encodes the enzyme catalyzing the methyl rearrangement reaction of the cobalamin biosynthesis pathway. The protein has been cloned and overexpressed as a His-tagged recombinant protein in Escherichia coli. The crystal structures have been solved in two crystal forms (P4(2)2(1)2 and P3(1)21) diffracting to 3.0 and 2.3A resolution, respectively. The structures are similar to the precorrin-8x methyl mutase (CobH), an enzyme of the aerobic pathway to vitamin B12.
About this Structure
2AFR is a Single protein structure of sequence from Leptospira interrogans. Full crystallographic information is available from OCA.
Reference
The crystal structure of putative precorrin isomerase CbiC in cobalamin biosynthesis., Xue Y, Wei Z, Li X, Gong W, J Struct Biol. 2006 Mar;153(3):307-11. Epub 2005 Dec 27. PMID:16427313
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