2ahm
From Proteopedia
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|PDB= 2ahm |SIZE=350|CAPTION= <scene name='initialview01'>2ahm</scene>, resolution 2.4Å | |PDB= 2ahm |SIZE=350|CAPTION= <scene name='initialview01'>2ahm</scene>, resolution 2.4Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ahm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ahm OCA], [http://www.ebi.ac.uk/pdbsum/2ahm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ahm RCSB]</span> | ||
}} | }} | ||
| Line 26: | Line 29: | ||
[[Category: Sun, F.]] | [[Category: Sun, F.]] | ||
[[Category: Zhai, Y J.]] | [[Category: Zhai, Y J.]] | ||
| - | [[Category: GOL]] | ||
| - | [[Category: SO4]] | ||
[[Category: coronavirus]] | [[Category: coronavirus]] | ||
[[Category: hexadecamer]] | [[Category: hexadecamer]] | ||
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[[Category: super-complex]] | [[Category: super-complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:52:47 2008'' |
Revision as of 22:52, 30 March 2008
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| , resolution 2.4Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of SARS-CoV super complex of non-structural proteins: the hexadecamer
Overview
Coronavirus replication and transcription machinery involves multiple virus-encoded nonstructural proteins (nsp). We report the crystal structure of the hexadecameric nsp7-nsp8 supercomplex from the severe acute respiratory syndrome coronavirus at 2.4-angstroms resolution. nsp8 has a novel 'golf-club' fold with two conformations. The supercomplex is a unique hollow, cylinder-like structure assembled from eight copies of nsp8 and held tightly together by eight copies of nsp7. With an internal diameter of approximately 30 angstroms, the central channel has dimensions and positive electrostatic properties favorable for nucleic acid binding, implying that its role is to confer processivity on RNA-dependent RNA polymerase.
About this Structure
2AHM is a Protein complex structure of sequences from Human sars coronavirus. Full crystallographic information is available from OCA.
Reference
Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer., Zhai Y, Sun F, Li X, Pang H, Xu X, Bartlam M, Rao Z, Nat Struct Mol Biol. 2005 Nov;12(11):980-6. PMID:16228002
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