2aiq
From Proteopedia
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|PDB= 2aiq |SIZE=350|CAPTION= <scene name='initialview01'>2aiq</scene>, resolution 1.54Å | |PDB= 2aiq |SIZE=350|CAPTION= <scene name='initialview01'>2aiq</scene>, resolution 1.54Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Venombin_A Venombin A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.74 3.4.21.74] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Venombin_A Venombin A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.74 3.4.21.74] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2aip|2AIP]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aiq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aiq OCA], [http://www.ebi.ac.uk/pdbsum/2aiq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2aiq RCSB]</span> | ||
}} | }} | ||
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[[Category: Arni, R K.]] | [[Category: Arni, R K.]] | ||
[[Category: Murakami, M T.]] | [[Category: Murakami, M T.]] | ||
| - | [[Category: ACT]] | ||
| - | [[Category: BEN]] | ||
| - | [[Category: CL]] | ||
| - | [[Category: GOL]] | ||
| - | [[Category: NAG]] | ||
| - | [[Category: NDG]] | ||
| - | [[Category: SO4]] | ||
[[Category: protein c activator]] | [[Category: protein c activator]] | ||
[[Category: snake venom serine proteinase]] | [[Category: snake venom serine proteinase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:53:14 2008'' |
Revision as of 22:53, 30 March 2008
| |||||||
| , resolution 1.54Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , , , | ||||||
| Activity: | Venombin A, with EC number 3.4.21.74 | ||||||
| Related: | 2AIP
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of benzamidine-inhibited protein C activator from the venom of copperhead snake Agkistrodon contortrix contortrix
Overview
Protein C activation initiated by the thrombin-thrombomodulin complex forms the major physiological anticoagulant pathway. Agkistrodon contortrix contortrix protein C activator, a glycosylated single-chain serine proteinase, activates protein C without relying on thrombomodulin. The crystal structures of native and inhibited Agkistrodon contortrix contortrix protein C activator determined at 1.65 and 1.54 A resolutions, respectively, indicate the pivotal roles played by the positively charged belt and the strategic positioning of the three carbohydrate moieties surrounding the catalytic site in protein C recognition, binding, and activation. Structural changes in the benzamidine-inhibited enzyme suggest a probable function in allosteric regulation for the anion-binding site located in the C-terminal extension, which is fully conserved in snake venom serine proteinases, that preferentially binds Cl(1-) instead of SO(4)(2-).
About this Structure
2AIQ is a Single protein structure of sequence from Agkistrodon contortrix contortrix. Full crystallographic information is available from OCA.
Reference
Thrombomodulin-independent activation of protein C and specificity of hemostatically active snake venom serine proteinases: crystal structures of native and inhibited Agkistrodon contortrix contortrix protein C activator., Murakami MT, Arni RK, J Biol Chem. 2005 Nov 25;280(47):39309-15. Epub 2005 Sep 14. PMID:16162508
Page seeded by OCA on Mon Mar 31 01:53:14 2008
