2alv
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2alv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2alv OCA], [http://www.ebi.ac.uk/pdbsum/2alv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2alv RCSB]</span> | ||
}} | }} | ||
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[[Category: Santarsiero, B D.]] | [[Category: Santarsiero, B D.]] | ||
[[Category: Xi, K.]] | [[Category: Xi, K.]] | ||
| - | [[Category: CY6]] | ||
[[Category: 3c]] | [[Category: 3c]] | ||
[[Category: 3cl]] | [[Category: 3cl]] | ||
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[[Category: sar]] | [[Category: sar]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:54:22 2008'' |
Revision as of 22:54, 30 March 2008
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| , resolution 1.90Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors
Overview
Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors.
About this Structure
2ALV is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.
Reference
Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors., Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD, J Med Chem. 2005 Nov 3;48(22):6767-71. PMID:16250632
Page seeded by OCA on Mon Mar 31 01:54:22 2008
Categories: Human sars coronavirus | Single protein | Baker, S C. | Fu, W. | Ghosh, A K. | Harcourt, B H. | Johnson, M E. | Mesecar, A D. | Ratia, K. | Rota, P A. | Santarsiero, B D. | Xi, K. | 3c | 3cl | 3clpro | Anti-viral | Coronavirus | Inhibitor | Protease | Proteinase | Sar
