2aph
From Proteopedia
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|PDB= 2aph |SIZE=350|CAPTION= <scene name='initialview01'>2aph</scene>, resolution 2.10Å | |PDB= 2aph |SIZE=350|CAPTION= <scene name='initialview01'>2aph</scene>, resolution 2.10Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=AMU:BETA-N-ACETYLMURAMIC+ACID'>AMU</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=GMA:4-AMIDO-4-CARBAMOYL-BUTYRIC+ACID'>GMA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= PGLYRP3, PGRPIA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= PGLYRP3, PGRPIA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1sk3|1SK3]], [[1sk4|1SK4]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aph OCA], [http://www.ebi.ac.uk/pdbsum/2aph PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2aph RCSB]</span> | ||
}} | }} | ||
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[[Category: Mariuzza, R A.]] | [[Category: Mariuzza, R A.]] | ||
[[Category: Roychowdjury, A.]] | [[Category: Roychowdjury, A.]] | ||
| - | [[Category: NH2]] | ||
| - | [[Category: SO4]] | ||
[[Category: complex]] | [[Category: complex]] | ||
[[Category: crystal structure]] | [[Category: crystal structure]] | ||
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[[Category: pgrp]] | [[Category: pgrp]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:55:34 2008'' |
Revision as of 22:55, 30 March 2008
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| , resolution 2.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , | ||||||
| Gene: | PGLYRP3, PGRPIA (Homo sapiens) | ||||||
| Related: | 1SK3, 1SK4
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of human PGRP-IalphaC in complex with muramyl pentapeptide
Overview
Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors of the innate immune system that bind bacterial peptidoglycans (PGNs). We determined the crystal structure, to 2.1 A resolution, of the C-terminal PGN-binding domain of human PGRP-I alpha in complex with a muramyl pentapeptide (MPP) from Gram-positive bacteria containing a complete peptide stem (L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala). The structure reveals important features not observed previously in the complex between PGRP-I alpha and a muramyl tripeptide lacking D-Ala at stem positions 4 and 5. Most notable are ligand-induced structural rearrangements in the PGN-binding site that are essential for entry of the C-terminal portion of the peptide stem and for locking MPP in the binding groove. We propose that similar structural rearrangements to accommodate the PGN stem likely characterize many PGRPs, both mammalian and insect.
About this Structure
2APH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human peptidoglycan recognition protein I alpha bound to a muramyl pentapeptide from Gram-positive bacteria., Guan R, Brown PH, Swaminathan CP, Roychowdhury A, Boons GJ, Mariuzza RA, Protein Sci. 2006 May;15(5):1199-206. PMID:16641493
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