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5gt7

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m (Protected "5gt7" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5gt7 is ON HOLD until Paper Publication
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==Crystal Structure of Arg-bound CASTOR1==
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<StructureSection load='5gt7' size='340' side='right' caption='[[5gt7]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5gt7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GT7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GT7 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gt8|5gt8]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GATSL3, CASTOR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gt7 OCA], [http://pdbe.org/5gt7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gt7 RCSB], [http://www.ebi.ac.uk/pdbsum/5gt7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gt7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GATL3_HUMAN GATL3_HUMAN]] Functions as an intracellular arginine sensor that regulates the TORC1 signaling pathway through the GATOR complex. As a homooligomer or a heterooligomer with GATSL2, directly binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of arginine to GATSL3 disrupts the interaction of GATSL3-containing oligomers with GATOR2 and activates the TORC1 signaling pathway.<ref>PMID:26972053</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human]]
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[[Category: Deng, D]]
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[[Category: Guo, L]]
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[[Category: Act domain]]
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[[Category: Arginine binding]]
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[[Category: Castor1]]
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[[Category: Gator2]]
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[[Category: Gatsl2]]
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[[Category: Mtor]]
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[[Category: Signaling protein]]

Revision as of 20:52, 15 November 2017

Crystal Structure of Arg-bound CASTOR1

5gt7, resolution 2.05Å

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