2atp
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= Cd8a, Lyt-2, Lyt2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Cd8b, Lyt-3, Lyt3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |GENE= Cd8a, Lyt-2, Lyt2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Cd8b, Lyt-3, Lyt3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1bqh|1BQH]], [[1nez|1NEZ]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2atp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2atp OCA], [http://www.ebi.ac.uk/pdbsum/2atp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2atp RCSB]</span> | ||
}} | }} | ||
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[[Category: Wang, J H.]] | [[Category: Wang, J H.]] | ||
[[Category: Wang, X.]] | [[Category: Wang, X.]] | ||
| - | [[Category: NAG]] | ||
[[Category: cd8aa]] | [[Category: cd8aa]] | ||
[[Category: cd8ab]] | [[Category: cd8ab]] | ||
[[Category: mhc]] | [[Category: mhc]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:57:13 2008'' |
Revision as of 22:57, 30 March 2008
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| , resolution 2.4Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | Cd8a, Lyt-2, Lyt2 (Mus musculus), Cd8b, Lyt-3, Lyt3 (Mus musculus) | ||||||
| Related: | 1BQH, 1NEZ
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of a CD8ab heterodimer
Overview
The crystal structure of a recombinant mouse single chain CD8alphabeta ectodomains at 2.4 A resolution reveals paired immunoglobulin variable region-like domains with a striking resemblance to CD8alphaalpha in size, shape, and surface electrostatic potential of complementarity-determining regions (CDR), despite <20% sequence identity between the CD8alpha and CD8beta subunits. Unlike the CD8alpha subunit(s) in the heterodimer or homodimer, the CDR1 loop of CD8beta tilts away from its corresponding CDR2 and CDR3 loops. Consistent with this observation, independent mutational studies reveal that alanine substitutions of residues in the CDR1 loop of CD8beta have no effect on CD8alphabeta coreceptor function, whereas mutations in CD8beta CDR2 and CDR3 loops abolish CD8alphabeta coreceptor activity. The implications of these findings and additional CD8alpha mutational studies for CD8alphabeta- versus CD8alphaalpha-MHCI binding are discussed.
About this Structure
2ATP is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer., Chang HC, Tan K, Ouyang J, Parisini E, Liu JH, Le Y, Wang X, Reinherz EL, Wang JH, Immunity. 2005 Dec;23(6):661-71. PMID:16356863
Page seeded by OCA on Mon Mar 31 01:57:13 2008
Categories: Mus musculus | Protein complex | Chang, H C. | Le, Y. | Liu, J H. | Ouyang, J. | Parisini, E. | Reinherz, E L. | Tan, K. | Wang, J H. | Wang, X. | Cd8aa | Cd8ab | Mhc
