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5g6d

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Revision as of 23:09, 15 November 2017

Structure of Bacillus subtilis Nitric Oxide Synthase in complex with 7-(((3-(Dimethylamino)benzyl)amino)methyl)quinolin-2-amine

Structural highlights

5g6d is a 1 chain structure with sequence from "vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , , ,
Related:	5g65, 5g66, 5g67, 5g68, 5g69, 5g6a, 5g6b, 5g6c, 5g6e, 5g6f, 5g6g, 5g6h, 5g6i, 5g6j, 5g6k, 5g6l, 5g6m, 5g6n, 5g6o, 5g6p, 5g6q
Activity:	Nitric-oxide synthase (NAD(P)H-dependent), with EC number 1.14.13.165
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[NOSO_BACSU] Catalyzes the production of nitric oxide.

Publication Abstract from PubMed

Nitric oxide (NO) is produced in Gram-positive pathogens Bacillus anthracis and Staphylococcus aureus by the bacterial isoform of nitric oxide synthase (NOS). Inhibition of bacterial nitric oxide synthase (bNOS) has been identified as a promising antibacterial strategy for targeting methicillin-resistant Staphylocoocus aureus1. One class of NOS inhibitors that demonstrates antimicrobial efficacy utilizes an aminoquinoline scaffold. Here we report on a variety of aminoquinolines that target the bacterial NOS active site, in part, by binding to a hydrophobic patch that is unique to bNOS. Through mutagenesis and crystallographic studies, our findings demonstrate that aminoquinolines are an excellent scaffold to further aid in the development of bNOS-specific inhibitors.

Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-based Inhibitors.,Holden JK, Lewis MC, Cinelli MA, Abdullatif Z, Pensa AV, Silverman RB, Poulos TL Biochemistry. 2016 Sep 8. PMID:27607918^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Holden JK, Lewis MC, Cinelli MA, Abdullatif Z, Pensa AV, Silverman RB, Poulos TL. Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-based Inhibitors. Biochemistry. 2016 Sep 8. PMID:27607918 doi:http://dx.doi.org/10.1021/acs.biochem.6b00786

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5g6d"

@@ Line 3: / Line 3: @@
 <StructureSection load='5g6d' size='340' side='right' caption='[[5g6d]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5g6d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G6D FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5g6d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G6D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G6D FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=JHT:7-[[[3-(DIMETHYLAMINO)PHENYL]METHYLAMINO]METHYL]QUINOLIN-2-AMINE'>JHT</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5g65|5g65]], [[5g66|5g66]], [[5g67|5g67]], [[5g68|5g68]], [[5g69|5g69]], [[5g6a|5g6a]], [[5g6b|5g6b]], [[5g6c|5g6c]], [[5g6e|5g6e]], [[5g6f|5g6f]], [[5g6g|5g6g]], [[5g6h|5g6h]], [[5g6i|5g6i]], [[5g6j|5g6j]], [[5g6k|5g6k]], [[5g6l|5g6l]], [[5g6m|5g6m]], [[5g6n|5g6n]], [[5g6o|5g6o]], [[5g6p|5g6p]], [[5g6q|5g6q]]</td></tr>
@@ Line 24: / Line 24: @@
 __TOC__
 </StructureSection>
+[[Category: Vibrio subtilis ehrenberg 1835]]
 [[Category: Holden, J K]]
 [[Category: Poulos, T L]]

5g6d

From Proteopedia

Revision as of 23:09, 15 November 2017

Structure of Bacillus subtilis Nitric Oxide Synthase in complex with 7-(((3-(Dimethylamino)benzyl)amino)methyl)quinolin-2-amine

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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