1dwu

From Proteopedia

(Difference between revisions)

Revision as of 06:52, 16 November 2017

Ribosomal protein L1

Structural highlights

1dwu is a 2 chain structure with sequence from Atcc 35097. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1cjs
Gene:	THE CORRESPONDING GENE IN E. COLI IS RPLA (ATCC 35097)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RL1_METTL] Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA. Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of ribosomal protein L1 from the archaeon Methanococcus thermolithotrophicus has been determined at 2.7 A resolution. The crystals belong to space group P2(1)2(1)2(1), with unit-cell parameters a = 67.0, b = 70.1, c = 106.3 A and two molecules per asymmetric unit. The structure was solved by the molecular-replacement method with AMoRe and refined with CNS to an R value of 18.9% and an R(free) of 25.4% in the resolution range 30-2.7 A. Comparison of this structure with those obtained previously for two L1 proteins from other sources (the bacterium Thermus thermophilus and the archaeon M. jannaschii) as well as detailed analysis of intermolecular contacts in the corresponding L1 crystals reveal structural invariants on the molecular surface which are probably important for binding the 23S ribosomal RNA and protein function within the ribosome.

Structure of ribosomal protein L1 from Methanococcus thermolithotrophicus. Functionally important structural invariants on the L1 surface.,Nevskaya N, Tishchenko S, Paveliev M, Smolinskaya Y, Fedorov R, Piendl W, Nakamura Y, Toyoda T, Garber M, Nikonov S Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1023-9. Epub, 2002 May 29. PMID:12037305^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Nevskaya N, Tishchenko S, Paveliev M, Smolinskaya Y, Fedorov R, Piendl W, Nakamura Y, Toyoda T, Garber M, Nikonov S. Structure of ribosomal protein L1 from Methanococcus thermolithotrophicus. Functionally important structural invariants on the L1 surface. Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1023-9. Epub, 2002 May 29. PMID:12037305

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dwu"

@@ Line 1: / Line 1: @@
-==RIBOSOMAL PROTEIN L1==
+==Ribosomal protein L1==
 <StructureSection load='1dwu' size='340' side='right' caption='[[1dwu]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 == Structural highlights ==
@@ Line 5: / Line 6: @@
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cjs|1cjs]]</td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">THE CORRESPONDING GENE IN E. COLI IS RPLA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2186 ATCC 35097])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dwu OCA], [http://pdbe.org/1dwu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dwu RCSB], [http://www.ebi.ac.uk/pdbsum/1dwu PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dwu OCA], [http://pdbe.org/1dwu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dwu RCSB], [http://www.ebi.ac.uk/pdbsum/1dwu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dwu ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 28: / Line 29: @@
 </div>
 <div class="pdbe-citations 1dwu" style="background-color:#fffaf0;"></div>
-==See Also==
-*[[Ribosomal protein L1|Ribosomal protein L1]]
 == References ==
 <references/>

1dwu

From Proteopedia

Revision as of 06:52, 16 November 2017

Ribosomal protein L1

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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