5f8b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<StructureSection load='5f8b' size='340' side='right' caption='[[5f8b]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
<StructureSection load='5f8b' size='340' side='right' caption='[[5f8b]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5f8b]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F8B FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5f8b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfu Aspfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F8B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PZS:(5~{S},8~{S},9~{R})-2-[(~{E})-HEX-1-ENYL]-8-METHOXY-3-METHYL-9-OXIDANYL-8-(PHENYLCARBONYL)-1-OXA-7-AZASPIRO[4.4]NON-2-ENE-4,6-DIONE'>PZS</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PZS:(5~{S},8~{S},9~{R})-2-[(~{E})-HEX-1-ENYL]-8-METHOXY-3-METHYL-9-OXIDANYL-8-(PHENYLCARBONYL)-1-OXA-7-AZASPIRO[4.4]NON-2-ENE-4,6-DIONE'>PZS</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f8b OCA], [http://pdbe.org/5f8b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f8b RCSB], [http://www.ebi.ac.uk/pdbsum/5f8b PDBsum]</span></td></tr>
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AFUA_8G00580 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=330879 ASPFU])</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f8b OCA], [http://pdbe.org/5f8b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f8b RCSB], [http://www.ebi.ac.uk/pdbsum/5f8b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f8b ProSAT]</span></td></tr>
</table>
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Geometric isomerization can expand the scope of biological activities of natural products. The observed chemical diversity among the pseurotin-type fungal secondary metabolites is in part generated by a trans to cis isomerization of an olefin. In vitro characterizations of pseurotin biosynthetic enzymes revealed that the glutathione S-transferase PsoE requires participation of the bifunctional C-methyltransferase/epoxidase PsoF to complete the trans to cis isomerization of the pathway intermediate presynerazol. The crystal structure of the PsoE/glutathione/presynerazol complex indicated stereospecific glutathione-presynerazol conjugate formation is the principal function of PsoE. Moreover, PsoF was identified to have an additional, unexpected oxidative isomerase activity, thus making it a trifunctional enzyme which is key to the complexity generation in pseurotin biosynthesis. Through the study, we identified a novel mechanism of accomplishing a seemingly simple trans to cis isomerization reaction.
 +
 +
Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.,Yamamoto T, Tsunematsu Y, Hara K, Suzuki T, Kishimoto S, Kawagishi H, Noguchi H, Hashimoto H, Tang Y, Hotta K, Watanabe K Angew Chem Int Ed Engl. 2016 May 17;55(21):6207-10. doi: 10.1002/anie.201600940. , Epub 2016 Apr 13. PMID:27072782<ref>PMID:27072782</ref>
 +
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 5f8b" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Aspfu]]
[[Category: Hara, K]]
[[Category: Hara, K]]
[[Category: Hashimoto, H]]
[[Category: Hashimoto, H]]

Revision as of 07:55, 16 November 2017

Crystallographic Structure of PsoE with Co

5f8b, resolution 2.54Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5f8b"
Personal tools