2b1o
From Proteopedia
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|PDB= 2b1o |SIZE=350|CAPTION= <scene name='initialview01'>2b1o</scene> | |PDB= 2b1o |SIZE=350|CAPTION= <scene name='initialview01'>2b1o</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= cadA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 Dictyostelium discoideum]) | |GENE= cadA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 Dictyostelium discoideum]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1yhp|1YHP]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b1o OCA], [http://www.ebi.ac.uk/pdbsum/2b1o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b1o RCSB]</span> | ||
}} | }} | ||
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[[Category: Sriskanthadevan, S.]] | [[Category: Sriskanthadevan, S.]] | ||
[[Category: Yang, D W.]] | [[Category: Yang, D W.]] | ||
| - | [[Category: CA]] | ||
[[Category: calcium]] | [[Category: calcium]] | ||
[[Category: cell adherison]] | [[Category: cell adherison]] | ||
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[[Category: nmr]] | [[Category: nmr]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:00:14 2008'' |
Revision as of 23:00, 30 March 2008
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| Ligands: | |||||||
| Gene: | cadA (Dictyostelium discoideum) | ||||||
| Related: | 1YHP
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution Structure of Ca2+-bound DdCAD-1
Overview
DdCAD-1 is a novel Ca(2+)-dependent cell adhesion molecule that lacks a hydrophobic signal peptide and a transmembrane domain. DdCAD-1 is expressed by the social amoeba Dictyostelium discoideum at the onset of development. It is synthesized as a soluble protein and then transported to the plasma membrane by contractile vacuoles. Here we describe the novel features of the solution structures of Ca(2+)-free and Ca(2+)-bound monomeric DdCAD-1. DdCAD-1 contains two beta-sandwich domains, belonging to the betagamma-crystallin and immunoglobulin fold classes, respectively. Whereas the N-terminal domain has a major role in homophilic binding, the C-terminal domain tethers the protein to the cell membrane. From structural and mutational analyses, we propose a model for the Ca(2+)-bound DdCAD-1 dimer as a basis for understanding DdCAD-1-mediated cell-cell adhesion at the molecular level. Our results provide new insights into Ca(2+)-dependent mechanisms for cell-cell adhesion.
About this Structure
2B1O is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.
Reference
Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion., Lin Z, Sriskanthadevan S, Huang H, Siu CH, Yang D, Nat Struct Mol Biol. 2006 Nov;13(11):1016-22. Epub 2006 Oct 22. PMID:17057715
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