5gwf
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==FraC with GlcNAc(6S) bound== | |
| - | + | <StructureSection load='5gwf' size='340' side='right' caption='[[5gwf]], [[Resolution|resolution]] 1.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5gwf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Actfr Actfr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GWF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NGY:2-(ACETYLAMINO)-2-DEOXY-6-O-SULFO-ALPHA-D-GLUCOPYRANOSE'>NGY</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gwf OCA], [http://pdbe.org/5gwf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gwf RCSB], [http://www.ebi.ac.uk/pdbsum/5gwf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gwf ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACTPC_ACTFR ACTPC_ACTFR]] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.<ref>PMID:19563820</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Actfr]] | ||
| + | [[Category: Caaveiro, J M.M]] | ||
| + | [[Category: Tsumoto, K]] | ||
| + | [[Category: Actinoporin]] | ||
| + | [[Category: Carbohydrate-protein interaction]] | ||
| + | [[Category: Cytolysin]] | ||
| + | [[Category: Lipid-protein interaction]] | ||
| + | [[Category: Nanopore]] | ||
| + | [[Category: Pore-forming toxin]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 08:32, 16 November 2017
FraC with GlcNAc(6S) bound
| |||||||||||
