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2b2q
From Proteopedia
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|PDB= 2b2q |SIZE=350|CAPTION= <scene name='initialview01'>2b2q</scene>, resolution 2.05Å | |PDB= 2b2q |SIZE=350|CAPTION= <scene name='initialview01'>2b2q</scene>, resolution 2.05Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEO:HYDROGEN+PEROXIDE'>PEO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] </span> |
|GENE= katG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 Burkholderia pseudomallei]) | |GENE= katG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 Burkholderia pseudomallei]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1mwv|1MWV]], [[2b2o|2B2O]], [[2b2r|2B2R]], [[2b2s|2B2S]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2q OCA], [http://www.ebi.ac.uk/pdbsum/2b2q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b2q RCSB]</span> | ||
}} | }} | ||
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[[Category: Switala, J.]] | [[Category: Switala, J.]] | ||
[[Category: Wiseman, B.]] | [[Category: Wiseman, B.]] | ||
| - | [[Category: HEM]] | ||
| - | [[Category: NA]] | ||
| - | [[Category: PEO]] | ||
| - | [[Category: TRS]] | ||
[[Category: catalase-peroxidase]] | [[Category: catalase-peroxidase]] | ||
[[Category: katg]] | [[Category: katg]] | ||
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[[Category: ph change]] | [[Category: ph change]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:00:39 2008'' |
Revision as of 23:00, 30 March 2008
| |||||||
| , resolution 2.05Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Gene: | katG (Burkholderia pseudomallei) | ||||||
| Activity: | Catalase, with EC number 1.11.1.6 | ||||||
| Related: | 1MWV, 2B2O, 2B2R, 2B2S
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of native catalase-peroxidase KATG AT pH7.5
Overview
The catalase reaction of catalase-peroxidases involves catalase-specific features built into a peroxidase core. An arginine, 20 A from the active-site heme, acts as a molecular switch moving between two conformations, one that activates heme oxidation and one that activates oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway in a peroxidase. The influence of the arginine is imparted to the heme through its association with or dissociation from a tyrosinate that modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi electron interaction of the heme with the adduct Trp.
About this Structure
2B2Q is a Single protein structure of sequence from Burkholderia pseudomallei. Full crystallographic information is available from OCA.
Reference
A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases., Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC, EMBO Rep. 2005 Dec;6(12):1156-62. PMID:16211084
Page seeded by OCA on Mon Mar 31 02:00:39 2008
