5ng2

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'''Unreleased structure'''
 
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The entry 5ng2 is ON HOLD until Paper Publication
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==Structure of RIP2K(D146N) with bound Staurosporine==
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<StructureSection load='5ng2' size='340' side='right' caption='[[5ng2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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Authors: Pellegrini, E., Cusack, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ng2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NG2 FirstGlance]. <br>
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Description: Structure of RIP2K(D146N) with bound Staurosporine
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=STU:STAUROSPORINE'>STU</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIPK2, CARDIAK, RICK, RIP2, UNQ277/PRO314/PRO34092 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ng2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ng2 OCA], [http://pdbe.org/5ng2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ng2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ng2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ng2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/RIPK2_HUMAN RIPK2_HUMAN]] Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.<ref>PMID:14638696</ref> <ref>PMID:17054981</ref> <ref>PMID:18079694</ref> <ref>PMID:21123652</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human]]
[[Category: Cusack, S]]
[[Category: Cusack, S]]
[[Category: Pellegrini, E]]
[[Category: Pellegrini, E]]
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[[Category: Inactive state]]
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[[Category: Kinase]]
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[[Category: Rip2k]]
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[[Category: Staurosporine]]
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[[Category: Transferase]]

Revision as of 10:50, 16 November 2017

Structure of RIP2K(D146N) with bound Staurosporine

5ng2, resolution 2.80Å

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