5k3n

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'''Unreleased structure'''
 
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The entry 5k3n is ON HOLD until Paper Publication
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==Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand binding domain complex with ML209==
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<StructureSection load='5k3n' size='340' side='right' caption='[[5k3n]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5k3n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K3N FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6Q6:(3S)-3-(2H-1,3-benzodioxol-5-yl)-1-[(3R,5S)-3,5-dimethylpiperidin-1-yl]-3-(2-hydroxy-4,6-dimethoxyphenyl)propan-1-one'>6Q6</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5k3m|5k3m]], [[5k3l|5k3l]], [[5k38|5k38]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RORC, NR1F3, RORG, RZRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k3n OCA], [http://pdbe.org/5k3n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k3n RCSB], [http://www.ebi.ac.uk/pdbsum/5k3n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k3n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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__TOC__
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</StructureSection>
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[[Category: Human]]
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[[Category: Huang, P]]
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[[Category: Lu, J]]
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[[Category: Rastinejad, F]]
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[[Category: Double helix]]
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[[Category: Protein binding]]

Revision as of 11:37, 16 November 2017

Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand binding domain complex with ML209

5k3n, resolution 2.67Å

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