5m4w
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of DNA AGCGA-quadruplex adopted by 15-mer oligonucleotide found in regulatory region of the PLEKHG3 human gene with G11 to I11 mutation, d(GCGAGGGAGCIAGGG),VK34_I11== | |
| + | <StructureSection load='5m4w' size='340' side='right' caption='[[5m4w]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5m4w]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M4W FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DI:2-DEOXYINOSINE-5-MONOPHOSPHATE'>DI</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m4w OCA], [http://pdbe.org/5m4w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m4w RCSB], [http://www.ebi.ac.uk/pdbsum/5m4w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m4w ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Here we describe AGCGA-quadruplexes, an unexpected addition to the well-known tetrahelical families, G-quadruplexes and i-motifs, that have been a focus of intense research due to their potential biological impact in G- and C-rich DNA regions, respectively. High-resolution structures determined by solution-state nuclear magnetic resonance (NMR) spectroscopy demonstrate that AGCGA-quadruplexes comprise four 5'-AGCGA-3' tracts and are stabilized by G-A and G-C base pairs forming GAGA- and GCGC-quartets, respectively. Residues in the core of the structure are connected with edge-type loops. Sequences of alternating 5'-AGCGA-3' and 5'-GGG-3' repeats could be expected to form G-quadruplexes, but are shown herein to form AGCGA-quadruplexes instead. Unique structural features of AGCGA-quadruplexes together with lower sensitivity to cation and pH variation imply their potential biological relevance in regulatory regions of genes responsible for basic cellular processes that are related to neurological disorders, cancer and abnormalities in bone and cartilage development. | ||
| - | + | Tetrahelical structural family adopted by AGCGA-rich regulatory DNA regions.,Kocman V, Plavec J Nat Commun. 2017 May 17;8:15355. doi: 10.1038/ncomms15355. PMID:28513602<ref>PMID:28513602</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5m4w" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kocman, V]] | ||
| + | [[Category: Plavec, J]] | ||
| + | [[Category: Agcga-quadruplex]] | ||
| + | [[Category: Agcga-quadruplex family]] | ||
| + | [[Category: Dna]] | ||
| + | [[Category: G-g n1-carboniyl symmetric base pair]] | ||
| + | [[Category: Inosine]] | ||
| + | [[Category: Plekhg3 gene]] | ||
Revision as of 11:41, 16 November 2017
Structure of DNA AGCGA-quadruplex adopted by 15-mer oligonucleotide found in regulatory region of the PLEKHG3 human gene with G11 to I11 mutation, d(GCGAGGGAGCIAGGG),VK34_I11
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