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5o1n

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m (Protected "5o1n" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5o1n is ON HOLD
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==Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with N-[(2S)-2-Pyrrolidinylmethyl]-trifluoromethanesulfonamide bound==
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<StructureSection load='5o1n' size='340' side='right' caption='[[5o1n]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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Authors: Kopec, J., Rembeza, E., Pena, I.A., Strain-Damerell, C., Goubin, S., Sethi, R., Velupillai, S., Talon, R., Collins, P., Krojer, T., McLaughlin, M., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., Brennan, P., von Delft, F., Arruda, P., Yue, W.W.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5o1n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O1N FirstGlance]. <br>
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Description: Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with N-[(2S)-2-Pyrrolidinylmethyl]-trifluoromethanesulfonamide bound
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9H8:1,1,1-tris(fluoranyl)-~{N}-[[(2~{S})-pyrrolidin-2-yl]methyl]methanesulfonamide'>9H8</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AASS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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[[Category: Goubin, S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o1n OCA], [http://pdbe.org/5o1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o1n RCSB], [http://www.ebi.ac.uk/pdbsum/5o1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o1n ProSAT]</span></td></tr>
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[[Category: Collins, P]]
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</table>
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[[Category: Burgess-Brown, N]]
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== Disease ==
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[[Category: Mclaughlin, M]]
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[[http://www.uniprot.org/uniprot/AASS_HUMAN AASS_HUMAN]] Hyperlysinemia;Saccharopinuria. The disease is caused by mutations affecting the gene represented in this entry. The protein represented in this entry is involved in disease pathogenesis. A selective decrease in mitochondrial NADP(H) levels due to NADK2 mutations causes a deficiency of NADPH-dependent mitochondrial enzymes, such as DECR1 and AASS.<ref>PMID:24847004</ref>
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[[Category: Velupillai, S]]
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== Function ==
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[[Category: Yue, W.W]]
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[[http://www.uniprot.org/uniprot/AASS_HUMAN AASS_HUMAN]] Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.
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[[Category: Kopec, J]]
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== References ==
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[[Category: Von Delft, F]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human]]
[[Category: Arrowsmith, C]]
[[Category: Arrowsmith, C]]
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[[Category: Talon, R]]
 
[[Category: Arruda, P]]
[[Category: Arruda, P]]
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[[Category: Pena, I.A]]
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[[Category: Bountra, C]]
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[[Category: Brennan, P]]
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[[Category: Burgess-Brown, N]]
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[[Category: Collins, P]]
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[[Category: Delft, F von]]
[[Category: Edwards, A]]
[[Category: Edwards, A]]
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[[Category: Strain-Damerell, C]]
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[[Category: Goubin, S]]
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[[Category: Kopec, J]]
[[Category: Krojer, T]]
[[Category: Krojer, T]]
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[[Category: Brennan, P]]
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[[Category: McLaughlin, M]]
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[[Category: Pena, I A]]
[[Category: Rembeza, E]]
[[Category: Rembeza, E]]
[[Category: Sethi, R]]
[[Category: Sethi, R]]
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[[Category: Bountra, C]]
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[[Category: Strain-Damerell, C]]
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[[Category: Talon, R]]
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[[Category: Velupillai, S]]
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[[Category: Yue, W W]]
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[[Category: Human aminoadipate semialdehyde synthase]]
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[[Category: Oxidoreductase]]

Revision as of 11:47, 16 November 2017

Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with N-[(2S)-2-Pyrrolidinylmethyl]-trifluoromethanesulfonamide bound

5o1n, resolution 2.28Å

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