2b53
From Proteopedia
| Line 5: | Line 5: | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=D23:6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE'>D23</scene> | |LIGAND= <scene name='pdbligand=D23:6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE'>D23</scene> | ||
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2b52|2B52]], [[2b54|2B54]], [[2b55|2B55]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b53 OCA], [http://www.ebi.ac.uk/pdbsum/2b53 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b53 RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Muckelbauer, J.]] | [[Category: Muckelbauer, J.]] | ||
| - | [[Category: D23]] | ||
[[Category: cell cycle]] | [[Category: cell cycle]] | ||
[[Category: cell division]] | [[Category: cell division]] | ||
| Line 32: | Line 34: | ||
[[Category: protein kinase]] | [[Category: protein kinase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:01:37 2008'' |
Revision as of 23:01, 30 March 2008
| |||||||
| , resolution 2.00Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 | ||||||
| Related: | 2B52, 2B54, 2B55
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325
Overview
Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.
About this Structure
2B53 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Quinazolines as cyclin dependent kinase inhibitors., Sielecki TM, Johnson TL, Liu J, Muckelbauer JK, Grafstrom RH, Cox S, Boylan J, Burton CR, Chen H, Smallwood A, Chang CH, Boisclair M, Benfield PA, Trainor GL, Seitz SP, Bioorg Med Chem Lett. 2001 May 7;11(9):1157-60. PMID:11354366
Page seeded by OCA on Mon Mar 31 02:01:37 2008
