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4zg9

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==Structural basis for inhibition of human autotaxin by four novel compounds==
==Structural basis for inhibition of human autotaxin by four novel compounds==
<StructureSection load='4zg9' size='340' side='right' caption='[[4zg9]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
<StructureSection load='4zg9' size='340' side='right' caption='[[4zg9]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zg9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZG9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zg9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZG9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4O2:3-[(11AS)-6-(4-FLUOROBENZYL)-1,3-DIOXO-5,6,11,11A-TETRAHYDRO-1H-IMIDAZO[1,5 1,6]PYRIDO[3,4-B]INDOL-2(3H)-YL]PROPANOIC+ACID'>4O2</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4O2:3-[(11AS)-6-(4-FLUOROBENZYL)-1,3-DIOXO-5,6,11,11A-TETRAHYDRO-1H-IMIDAZO[1,5 1,6]PYRIDO[3,4-B]INDOL-2(3H)-YL]PROPANOIC+ACID'>4O2</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zg6|4zg6]], [[4zg7|4zg7]], [[4zga|4zga]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zg6|4zg6]], [[4zg7|4zg7]], [[4zga|4zga]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ENPP2, ATX, PDNP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylglycerophosphoethanolamine_phosphodiesterase Alkylglycerophosphoethanolamine phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.39 3.1.4.39] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylglycerophosphoethanolamine_phosphodiesterase Alkylglycerophosphoethanolamine phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.39 3.1.4.39] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zg9 OCA], [http://pdbe.org/4zg9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zg9 RCSB], [http://www.ebi.ac.uk/pdbsum/4zg9 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zg9 OCA], [http://pdbe.org/4zg9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zg9 RCSB], [http://www.ebi.ac.uk/pdbsum/4zg9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zg9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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</StructureSection>
</StructureSection>
[[Category: Alkylglycerophosphoethanolamine phosphodiesterase]]
[[Category: Alkylglycerophosphoethanolamine phosphodiesterase]]
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[[Category: Human]]
[[Category: Bain, G]]
[[Category: Bain, G]]
[[Category: Evans, J F]]
[[Category: Evans, J F]]

Revision as of 14:34, 16 November 2017

Structural basis for inhibition of human autotaxin by four novel compounds

4zg9, resolution 2.95Å

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