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4x6j

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==Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.==
==Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.==
<StructureSection load='4x6j' size='340' side='right' caption='[[4x6j]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
<StructureSection load='4x6j' size='340' side='right' caption='[[4x6j]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4x6j]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X6J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X6J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4x6j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X6J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X6J FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3Y2:2-AMINO-4-CHLORO-N-(1-{[(2E)-2-IMINOETHYL]CARBAMOYL}CYCLOHEXYL)BENZAMIDE'>3Y2</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3Y2:2-AMINO-4-CHLORO-N-(1-{[(2E)-2-IMINOETHYL]CARBAMOYL}CYCLOHEXYL)BENZAMIDE'>3Y2</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSK, CTSO, CTSO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x6j OCA], [http://pdbe.org/4x6j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x6j RCSB], [http://www.ebi.ac.uk/pdbsum/4x6j PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x6j OCA], [http://pdbe.org/4x6j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x6j RCSB], [http://www.ebi.ac.uk/pdbsum/4x6j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x6j ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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</StructureSection>
</StructureSection>
[[Category: Cathepsin K]]
[[Category: Cathepsin K]]
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[[Category: Human]]
[[Category: Borisek, J]]
[[Category: Borisek, J]]
[[Category: Mohar, B]]
[[Category: Mohar, B]]

Revision as of 16:17, 16 November 2017

Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.

4x6j, resolution 1.59Å

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