2b9b
From Proteopedia
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
| - | |GENE= F ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= | + | |GENE= F ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11207 Simian virus 5]) |
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b9b OCA], [http://www.ebi.ac.uk/pdbsum/2b9b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2b9b RCSB]</span> | ||
}} | }} | ||
| Line 16: | Line 19: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2B9B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ | + | 2B9B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_virus_5 Simian virus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9B OCA]. |
==Reference== | ==Reference== | ||
Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation., Yin HS, Wen X, Paterson RG, Lamb RA, Jardetzky TS, Nature. 2006 Jan 5;439(7072):38-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16397490 16397490] | Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation., Yin HS, Wen X, Paterson RG, Lamb RA, Jardetzky TS, Nature. 2006 Jan 5;439(7072):38-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16397490 16397490] | ||
| - | [[Category: Simian virus | + | [[Category: Simian virus 5]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Jardetzky, T S.]] | [[Category: Jardetzky, T S.]] | ||
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[[Category: Wen, X.]] | [[Category: Wen, X.]] | ||
[[Category: Yin, H S.]] | [[Category: Yin, H S.]] | ||
| - | [[Category: NAG]] | ||
[[Category: fusion protein]] | [[Category: fusion protein]] | ||
[[Category: pre-fusion conformation]] | [[Category: pre-fusion conformation]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:03:12 2008'' |
Revision as of 23:03, 30 March 2008
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| , resolution 2.85Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | F (Simian virus 5) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the Parainfluenza Virus 5 F Protein in its Metastable, Pre-fusion Conformation
Overview
Enveloped viruses have evolved complex glycoprotein machinery that drives the fusion of viral and cellular membranes, permitting entry of the viral genome into the cell. For the paramyxoviruses, the fusion (F) protein catalyses this membrane merger and entry step, and it has been postulated that the F protein undergoes complex refolding during this process. Here we report the crystal structure of the parainfluenza virus 5 F protein in its prefusion conformation, stabilized by the addition of a carboxy-terminal trimerization domain. The structure of the F protein shows that there are profound conformational differences between the pre- and postfusion states, involving transformations in secondary and tertiary structure. The positions and structural transitions of key parts of the fusion machinery, including the hydrophobic fusion peptide and two helical heptad repeat regions, clarify the mechanism of membrane fusion mediated by the F protein.
About this Structure
2B9B is a Single protein structure of sequence from Simian virus 5. Full crystallographic information is available from OCA.
Reference
Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation., Yin HS, Wen X, Paterson RG, Lamb RA, Jardetzky TS, Nature. 2006 Jan 5;439(7072):38-44. PMID:16397490
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