ATP-dependent Clp protease adaptor protein

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: <StructureSection load='3o2h' size='340' side='right' caption='E. coli ClpS complex with peptide (PDB code 3o2h)' scene=''> == Function == '''ATP-dependent Clp protease adaptor pro...)
Line 1: Line 1:
-
 
+
<StructureSection load='3o2h' size='340' side='right' caption='E. coli ClpS (grey) complex with peptide (green) (PDB code [[3o2h]])' scene=''>
-
<StructureSection load='3o2h' size='340' side='right' caption='E. coli ClpS complex with peptide (PDB code [[3o2h]])' scene=''>
+
== Function ==
== Function ==
-
'''ATP-dependent Clp protease adaptor protein''' (ClpS) influences the protein degradation by binding to the chaperone-protease ClpAP toward degradation of aggregated proteins<ref>PMID:11931773</ref>.
+
'''ATP-dependent Clp protease adaptor protein''' (ClpS) influences the protein degradation by binding to the chaperone-protease ClpAP toward degradation of aggregated proteins<ref>PMID:11931773</ref>. Degradation susceptibility is related to N-terminal residues. It is formulated by the N-end rule<ref>PMID:18708349</ref>. In bacteria the residues are Tyr, Phe, Trp and Leu. ClpS binds these residues and delivers the protein to degradation by ClpAP<ref>PMID:19373253</ref>.
-
 
+
-
== Disease ==
+
-
 
+
-
== Relevance ==
+
== Structural highlights ==
== Structural highlights ==
 +
ClpS His residue binds to the N-terminal Leu which is one of the N-end rule residues<ref>PMID:11931773</ref>.
</StructureSection>
</StructureSection>

Revision as of 09:27, 21 November 2017

E. coli ClpS (grey) complex with peptide (green) (PDB code 3o2h)

Drag the structure with the mouse to rotate

3D Structures of ATP-dependent Clp protease adaptor protein

Updated on 21-November-2017

3o2o, 3o1f – EcClpS – Escherichia coli
1r6o, 1r6q – EcClpS + ClpA
3o2b, 3o2h, 2wa9, 2w9r, 2wa8 – EcClpS + peptide
3gq0 – CvClpS – Caulobacter vibrioides
3g19, 3gq1, 3gw1, 3dnj – CvClpS + peptide
3g1b, 3g3p – CvClpS (mutant) + peptide
4yjm – AtClpS 2 – Agrobacterium tumefaciens
4yjx, 4yka – AtClpS 2 + amino acid

References

  1. ↑ Dougan DA, Reid BG, Horwich AL, Bukau B. ClpS, a substrate modulator of the ClpAP machine. Mol Cell. 2002 Mar;9(3):673-83. PMID:11931773
  2. ↑ Varshavsky A. Discovery of cellular regulation by protein degradation. J Biol Chem. 2008 Dec 12;283(50):34469-89. doi: 10.1074/jbc.X800009200. Epub 2008, Aug 15. PMID:18708349 doi:http://dx.doi.org/10.1074/jbc.X800009200
  3. ↑ Schuenemann VJ, Kralik SM, Albrecht R, Spall SK, Truscott KN, Dougan DA, Zeth K. Structural basis of N-end rule substrate recognition in Escherichia coli by the ClpAP adaptor protein ClpS. EMBO Rep. 2009 May;10(5):508-14. Epub 2009 Apr 17. PMID:19373253 doi:10.1038/embor.2009.62
  4. ↑ Dougan DA, Reid BG, Horwich AL, Bukau B. ClpS, a substrate modulator of the ClpAP machine. Mol Cell. 2002 Mar;9(3):673-83. PMID:11931773

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/ATP-dependent_Clp_protease_adaptor_protein"
Personal tools