6axj

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m (Protected "6axj" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6axj is ON HOLD
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==Crystal structure of the Yaf9 YEATS domain bound to H3K27ac==
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<StructureSection load='6axj' size='340' side='right' caption='[[6axj]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6axj]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AXJ FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6axj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6axj OCA], [http://pdbe.org/6axj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6axj RCSB], [http://www.ebi.ac.uk/pdbsum/6axj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6axj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/AF9_YEAST AF9_YEAST]] Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.<ref>PMID:14690608</ref> <ref>PMID:12917332</ref> <ref>PMID:15485911</ref> <ref>PMID:15045029</ref> <ref>PMID:14645854</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Klein, B J]]
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[[Category: Kutateladze, T G]]
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[[Category: Epigenetic]]
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[[Category: Gene regulation]]
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[[Category: Transcription]]

Revision as of 07:47, 22 November 2017

Crystal structure of the Yaf9 YEATS domain bound to H3K27ac

6axj, resolution 2.38Å

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