4o04
From Proteopedia
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<StructureSection load='4o04' size='340' side='right' caption='[[4o04]], [[Resolution|resolution]] 1.82Å' scene=''> | <StructureSection load='4o04' size='340' side='right' caption='[[4o04]], [[Resolution|resolution]] 1.82Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4o04]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O04 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4o04]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O04 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2Q8:4-(2,7,7-TRIMETHYL-5-OXO-1,2,3,4,5,6,7,8-OCTAHYDRO-9H-BETA-CARBOLIN-9-YL)BENZAMIDE'>2Q8</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2Q8:4-(2,7,7-TRIMETHYL-5-OXO-1,2,3,4,5,6,7,8-OCTAHYDRO-9H-BETA-CARBOLIN-9-YL)BENZAMIDE'>2Q8</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o05|4o05]], [[4o06|4o06]], [[4o09|4o09]], [[4o0b|4o0b]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o05|4o05]], [[4o06|4o06]], [[4o09|4o09]], [[4o0b|4o0b]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o04 OCA], [http://pdbe.org/4o04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o04 RCSB], [http://www.ebi.ac.uk/pdbsum/4o04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o04 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o04 OCA], [http://pdbe.org/4o04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o04 RCSB], [http://www.ebi.ac.uk/pdbsum/4o04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o04 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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</div> | </div> | ||
<div class="pdbe-citations 4o04" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4o04" style="background-color:#fffaf0;"></div> | ||
| - | |||
| - | ==See Also== | ||
| - | *[[Heat Shock Proteins|Heat Shock Proteins]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Ernst, J]] | [[Category: Ernst, J]] | ||
[[Category: Zuccola, H J]] | [[Category: Zuccola, H J]] | ||
[[Category: Chaperone]] | [[Category: Chaperone]] | ||
[[Category: Chaperone-chaperone inhibitor complex]] | [[Category: Chaperone-chaperone inhibitor complex]] | ||
Revision as of 08:19, 22 November 2017
Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease
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