4p9i
From Proteopedia
(Difference between revisions)
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<StructureSection load='4p9i' size='340' side='right' caption='[[4p9i]], [[Resolution|resolution]] 1.34Å' scene=''> | <StructureSection load='4p9i' size='340' side='right' caption='[[4p9i]], [[Resolution|resolution]] 1.34Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4p9i]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9I FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4p9i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9I FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9i OCA], [http://pdbe.org/4p9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p9i RCSB], [http://www.ebi.ac.uk/pdbsum/4p9i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p9i ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ryr2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9i OCA], [http://pdbe.org/4p9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p9i RCSB], [http://www.ebi.ac.uk/pdbsum/4p9i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p9i ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/RYR2_MOUSE RYR2_MOUSE]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10473538</ref> <ref>PMID:9628868</ref> <ref>PMID:21098440</ref> <ref>PMID:20431056</ref> | [[http://www.uniprot.org/uniprot/RYR2_MOUSE RYR2_MOUSE]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10473538</ref> <ref>PMID:9628868</ref> <ref>PMID:21098440</ref> <ref>PMID:20431056</ref> | ||
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| - | ==See Also== | ||
| - | *[[Ryanodine receptor|Ryanodine receptor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Lk3 transgenic mice]] | ||
[[Category: Lau, K]] | [[Category: Lau, K]] | ||
[[Category: Petegem, F Van]] | [[Category: Petegem, F Van]] | ||
Revision as of 08:36, 22 November 2017
Crystal Structure of mouse Ryanodine Receptor 2 SPRY2 Domain (1080-1253)
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