4q7g

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(Difference between revisions)

Revision as of 08:50, 22 November 2017

1.7 Angstrom Crystal Structure of leukotoxin LukD from Staphylococcus aureus.

Structural highlights

4q7g is a 1 chain structure with sequence from Staas. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	hlgB, lukD, lukDv, SAS1748 (STAAS)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[LUKDV_STAAS] Part of a bi-component leucotoxin that acts by forming pores in the membrane of the target cells. The activity of LukEv-LukDv to rabbit leukocytes is similar to that of the Panton-Valentine leucocidin (PVL). LukEv-LukDv is hemolytic to rabbit red blood cells although the activity is only 8% of gamma-hemolysin (By similarity).

Publication Abstract from PubMed

Staphylococcal leukotoxins are a family of beta-barrel, bicomponent, pore-forming toxins with membrane-damaging functions. These bacterial exotoxins share sequence and structural homology and target several host-cell types. Leukotoxin ED (LukED) is one of these bicomponent pore-forming toxins that Staphylococcus aureus produces in order to suppress the ability of the host to contain the infection. The recent delineation of the important role that LukED plays in S. aureus pathogenesis and the identification of its protein receptors, combined with its presence in S. aureus methicillin-resistant epidemic strains, establish this leukocidin as a possible target for the development of novel therapeutics. Here, the crystal structures of the water-soluble LukE and LukD components of LukED have been determined. The two structures illustrate the tertiary-structural variability with respect to the other leukotoxins while retaining the conservation of the residues involved in the interaction of the protomers in the bipartite leukotoxin in the pore complex.

Crystal structures of the components of the Staphylococcus aureus leukotoxin ED.,Nocadello S, Minasov G, Shuvalova L, Dubrovska I, Sabini E, Bagnoli F, Grandi G, Anderson WF Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):113-20. doi:, 10.1107/S2059798315023207. Epub 2016 Jan 1. PMID:26894539^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Nocadello S, Minasov G, Shuvalova L, Dubrovska I, Sabini E, Bagnoli F, Grandi G, Anderson WF. Crystal structures of the components of the Staphylococcus aureus leukotoxin ED. Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):113-20. doi:, 10.1107/S2059798315023207. Epub 2016 Jan 1. PMID:26894539 doi:http://dx.doi.org/10.1107/S2059798315023207

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4q7g"

@@ Line 3: / Line 3: @@
 <StructureSection load='4q7g' size='340' side='right' caption='[[4q7g]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4q7g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q7G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q7G FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4q7g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staas Staas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q7G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q7G FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q7g OCA], [http://pdbe.org/4q7g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q7g RCSB], [http://www.ebi.ac.uk/pdbsum/4q7g PDBsum]</span></td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hlgB, lukD, lukDv, SAS1748 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=282459 STAAS])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q7g OCA], [http://pdbe.org/4q7g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q7g RCSB], [http://www.ebi.ac.uk/pdbsum/4q7g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q7g ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 22: / Line 23: @@
 __TOC__
 </StructureSection>
+[[Category: Staas]]
 [[Category: Anderson, W F]]
 [[Category: Bagnoli, F]]

4q7g

From Proteopedia

Revision as of 08:50, 22 November 2017

1.7 Angstrom Crystal Structure of leukotoxin LukD from Staphylococcus aureus.

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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