2bgd
From Proteopedia
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|PDB= 2bgd |SIZE=350|CAPTION= <scene name='initialview01'>2bgd</scene>, resolution 2.40Å | |PDB= 2bgd |SIZE=350|CAPTION= <scene name='initialview01'>2bgd</scene>, resolution 2.40Å | ||
|SITE= <scene name='pdbsite=AC1:Po4+Binding+Site+For+Chain+A'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Po4+Binding+Site+For+Chain+A'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=T1D:5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE+1,1-DIOXIDE'>T1D</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bgd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bgd OCA], [http://www.ebi.ac.uk/pdbsum/2bgd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bgd RCSB]</span> | ||
}} | }} | ||
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==Overview== | ==Overview== | ||
Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template. | Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template. | ||
| - | |||
| - | ==Disease== | ||
| - | Known diseases associated with this structure: Abdominal body fat distribution, modifier of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176885 176885]], Insulin resistance, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176885 176885]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Toader, D.]] | [[Category: Toader, D.]] | ||
[[Category: Tucker, J.]] | [[Category: Tucker, J.]] | ||
| - | [[Category: | + | [[Category: 1,2,5-thiadiazolidin-3-one-1]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
[[Category: 1-dioxide template]] | [[Category: 1-dioxide template]] | ||
| - | [[Category: 2]] | ||
| - | [[Category: 5-thiadiazolidin-3-one-1]] | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
[[Category: protein tyrosine phosphatase]] | [[Category: protein tyrosine phosphatase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:06:02 2008'' |
Revision as of 23:06, 30 March 2008
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| , resolution 2.40Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , , | ||||||
| Activity: | Protein-tyrosine-phosphatase, with EC number 3.1.3.48 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE-BASED DESIGN OF PROTEIN TYROSINE PHOSPHATASE-1B INHIBITORS
Overview
Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.
About this Structure
2BGD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure-based design of protein tyrosine phosphatase-1B inhibitors., Black E, Breed J, Breeze AL, Embrey K, Garcia R, Gero TW, Godfrey L, Kenny PW, Morley AD, Minshull CA, Pannifer AD, Read J, Rees A, Russell DJ, Toader D, Tucker J, Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7. PMID:15863305
Page seeded by OCA on Mon Mar 31 02:06:02 2008
Categories: Homo sapiens | Protein-tyrosine-phosphatase | Single protein | Black, E. | Breed, J. | Breeze, A L. | Embrey, K. | Garcia, R. | Gero, T W. | Godfrey, L. | Kenny, P W. | Minshull, C A. | Morley, A D. | Pannifer, A D. | Read, J. | Rees, A. | Russell, D J. | Toader, D. | Tucker, J. | 1,2,5-thiadiazolidin-3-one-1 | 1-dioxide template | Hydrolase | Protein tyrosine phosphatase
