4xq5

From Proteopedia

(Difference between revisions)

Revision as of 09:36, 22 November 2017

Human-infecting H10N8 influenza virus retains strong preference for avian-type receptors

Structural highlights

4xq5 is a 6 chain structure with sequence from Influenza a virus (a/jiangxi-donghu/346/2013(h10n8)). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	4xqu, 4xqo
Gene:	HA (Influenza A virus (A/Jiangxi-Donghu/346/2013(H10N8)))
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[A0A059T4A1_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00046810]

Publication Abstract from PubMed

Recent avian-origin H10N8 influenza A viruses that have infected humans pose a potential pandemic threat. Alterations in the viral surface glycoprotein, hemagglutinin (HA), typically are required for influenza A viruses to cross the species barrier for adaptation to a new host, but whether H10N8 contains adaptations supporting human infection remains incompletely understood. We investigated whether H10N8 HA can bind human receptors. Sialoside glycan microarray analysis showed that the H10 HA retains a strong preference for avian receptor analogs and negligible binding to human receptor analogs. Crystal structures of H10 HA with avian and human receptor analogs revealed the basis for preferential recognition of avian-like receptors. Furthermore, introduction of mutations into the H10 receptor-binding site (RBS) known to convert other HA subtypes from avian to human receptor specificity failed to switch preference to human receptors. Collectively, these findings suggest that the current H10N8 human isolates are poorly adapted for efficient human-to-human transmission.

A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors.,Zhang H, de Vries RP, Tzarum N, Zhu X, Yu W, McBride R, Paulson JC, Wilson IA Cell Host Microbe. 2015 Mar 11;17(3):377-84. doi: 10.1016/j.chom.2015.02.006. PMID:25766296^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Zhang H, de Vries RP, Tzarum N, Zhu X, Yu W, McBride R, Paulson JC, Wilson IA. A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors. Cell Host Microbe. 2015 Mar 11;17(3):377-84. doi: 10.1016/j.chom.2015.02.006. PMID:25766296 doi:http://dx.doi.org/10.1016/j.chom.2015.02.006

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4xq5"

Categories: Tzarum, N | Wilson, I A | Zhang, H | Zhu, X | Viral protein

@@ Line 3: / Line 3: @@
 <StructureSection load='4xq5' size='340' side='right' caption='[[4xq5]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4xq5]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XQ5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4xq5]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/jiangxi-donghu/346/2013(h10n8)) Influenza a virus (a/jiangxi-donghu/346/2013(h10n8))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XQ5 FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xqu|4xqu]], [[4xqo|4xqo]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1458555 Influenza A virus (A/Jiangxi-Donghu/346/2013(H10N8))])</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xq5 OCA], [http://pdbe.org/4xq5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xq5 RCSB], [http://www.ebi.ac.uk/pdbsum/4xq5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xq5 ProSAT]</span></td></tr>
 </table>
@@ Line 19: / Line 20: @@
 </div>
 <div class="pdbe-citations 4xq5" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Hemagglutinin|Hemagglutinin]]
 == References ==
 <references/>

4xq5

From Proteopedia

Revision as of 09:36, 22 November 2017

Human-infecting H10N8 influenza virus retains strong preference for avian-type receptors

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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