2biw
From Proteopedia
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|PDB= 2biw |SIZE=350|CAPTION= <scene name='initialview01'>2biw</scene>, resolution 2.39Å | |PDB= 2biw |SIZE=350|CAPTION= <scene name='initialview01'>2biw</scene>, resolution 2.39Å | ||
|SITE= <scene name='pdbsite=AC1:Fe+Binding+Site+For+Chain+D'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Fe+Binding+Site+For+Chain+D'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=3ON:(3R)-3-HYDROXY-8'-APOCAROTENOL'>3ON</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2biw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2biw OCA], [http://www.ebi.ac.uk/pdbsum/2biw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2biw RCSB]</span> | ||
}} | }} | ||
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[[Category: Ruch, S.]] | [[Category: Ruch, S.]] | ||
[[Category: Schulz, G E.]] | [[Category: Schulz, G E.]] | ||
| - | [[Category: 3ON]] | ||
| - | [[Category: FE]] | ||
| - | [[Category: carotenoid cleavage]] | ||
[[Category: dioxygenase]] | [[Category: dioxygenase]] | ||
| - | [[Category: non-heme iron]] | ||
[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | [[Category: oxygenase | + | [[Category: oxygenase,non-heme iron,carotenoid cleavage,retinal formation]] |
| - | + | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:07:07 2008'' |
Revision as of 23:07, 30 March 2008
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| , resolution 2.39Å | |||||||
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| Sites: | |||||||
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF APOCAROTENOID CLEAVAGE OXYGENASE FROM SYNECHOCYSTIS, NATIVE ENZYME
Overview
Enzymes that produce retinal and related apocarotenoids constitute a sequence- and thus structure-related family, a member of which was analyzed by x-ray diffraction. This member is an oxygenase and contains an Fe2+-4-His arrangement at the axis of a seven-bladed beta-propeller chain fold covered by a dome formed by six large loops. The Fe2+ is accessible through a long nonpolar tunnel that holds a carotenoid derivative in one of the crystals. On binding, three consecutive double bonds of this carotenoid changed from a straight all-trans to a cranked cis-trans-cis conformation. The remaining trans bond is located at the dioxygen-ligated Fe2+ and cleaved by oxygen.
About this Structure
2BIW is a Single protein structure of sequence from Synechocystis sp.. The following page contains interesting information on the relation of 2BIW with [Carotenoid Oxygenase]. Full crystallographic information is available from OCA.
Reference
The structure of a retinal-forming carotenoid oxygenase., Kloer DP, Ruch S, Al-Babili S, Beyer P, Schulz GE, Science. 2005 Apr 8;308(5719):267-9. PMID:15821095
Page seeded by OCA on Mon Mar 31 02:07:07 2008
